| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.31.1.1 | The Ly-6/neurotoxin-like protein1 precursor, Lynx1. The NMR structure is available (Lyukmanova et al. 2011). | Eukaryota |
Metazoa, Chordata | Lynx1 of Homo sapiens (Q9BZG9) |
|
8.A.31.1.2 | Ly6/PLAUR domain-containing protein of 183 aas | Eukaryota |
Metazoa, Chordata | Ly6/PLAUR domain-containing protein of Homo sapiens |
|
8.A.31.1.3 | The secreted Ly-6/uPAR-related protein, SLURP-1 of 103 aas and 1 or 2 TMSs. It is found in epithelium, sensory neurons and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation skin disease, Mal de Meleda. SLURP-1 is considered an autocrine/paracrine hormone that regulates growth and differentiation of keratinocytes and controls inflammation and malignant cell transformation. The antiproliferative activity of SLURP-1 is related to the 'metabotropic' signaling pathway through α7-nAChR, that activates intracellular signaling cascades without opening the receptor channel (Lyukmanova et al. 2016). Thus, SLURP-1 is an allosteric antogonist of the α7 nicotinic acetylcholine receptor. | Eukaryota |
Metazoa, Chordata | SLURP-1 of Homo sapiens |
|
8.A.31.1.4 | Prostate and testis expressed protein 4, PATE4 or SVS VII, is a heat labile phospholipid binding protein of 99 aas with 1 N-terminal TMS. It enhances sperm motility and binds to calmodulin to inhibit calcium transport into spermatozoa. It may also modulate the function of nicotinic acetylcholine receptors (Luo et al. 2001). | Eukaryota |
Metazoa, Chordata | PATE4 of Mus musculus |