8.A.43.1.11
Leucine-rich repeat transmembrane neuronal protein 1, LRRTM1 of 522 aas and 2 TMSs, N- and C-terminal. It exhibits strong synaptogenic activity, and is
restricted to excitatory presynaptic differentiation, acting at both
pre- and postsynaptic levels. It helps stabilize synaptic AMPA receptors at mature spines during basal synaptic transmission and LTP (Bhouri et al. 2018).
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| Accession Number: | Q86UE6 |
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| Protein Name: | Leucine-rich repeat transmembrane neuronal protein 1 |
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| Length: | 522 |
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| Molecular Weight: | 58641.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNLTEA
61: PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL
121: SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI
181: FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL
241: RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL
301: NSWKSLTSIT LAGNLWDCGR NVCALASWLN NFQGRYDGNL QCASPEYAQG EDVLDAVYAF
361: HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG QHDGTFEPAT VALPGGEHAE
421: NAVQIHKVVT GTMALIFSFL IVVLVLYVSW KCFPASLRQL RQCFVTQRRK QKQKQTMHQM
481: AAMSAQEYYV DYKPNHIEGA LVIINEYGSC TCHQQPAREC EV