8.A.43.1.20
Leucine-rich repeat transmembrane neuronal protein 4, LRRTM4, of 590 aas and two TMSs, one at the N-terminus, and one near the C-terminus. It may play a role in the development and maintenance
of the vertebrate nervous system. It exhibits strong synaptogenic
activity but is restricted to excitatory presynaptic differentiation. It is a member of the transsynaptic complex between rod photoreceptors and bipolar cells (Agosto and Wensel 2020).
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| Accession Number: | Q86VH4 |
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| Protein Name: | Leucine-rich repeat transmembrane neuronal protein 4 |
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| Length: | 590 |
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| Molecular Weight: | 67217.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MGFHLITQLK GMSVVLVLLP TLLLVMLTGA QRACPKNCRC DGKIVYCESH AFADIPENIS
61: GGSQGLSLRF NSIQKLKSNQ FAGLNQLIWL YLDHNYISSV DEDAFQGIRR LKELILSSNK
121: ITYLHNKTFH PVPNLRNLDL SYNKLQTLQS EQFKGLRKLI ILHLRSNSLK TVPIRVFQDC
181: RNLDFLDLGY NRLRSLSRNA FAGLLKLKEL HLEHNQFSKI NFAHFPRLFN LRSIYLQWNR
241: IRSISQGLTW TWSSLHNLDL SGNDIQGIEP GTFKCLPNLQ KLNLDSNKLT NISQETVNAW
301: ISLISITLSG NMWECSRSIC PLFYWLKNFK GNKESTMICA GPKHIQGEKV SDAVETYNIC
361: SEVQVVNTER SHLVPQTPQK PLIIPRPTIF KPDVTQSTFE TPSPSPGFQI PGAEQEYEHV
421: SFHKIIAGSV ALFLSVAMIL LVIYVSWKRY PASMKQLQQH SLMKRRRKKA RESERQMNSP
481: LQEYYVDYKP TNSETMDISV NGSGPCTYTI SGSRECEMPH HMKPLPYYSY DQPVIGYCQA
541: HQPLHVTKGY ETVSPEQDES PGLELGRDHS FIATIARSAA PAIYLERIAN