Adenylyl cyclase 8 of 1251 aas and 12 TMSs in a 6 + 6 TMS pattern. It catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affects processes suche as synaptic plasticity and insulin secretion. It plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. It  also plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and the glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation, leading to vesicle pool replenishment. A dual inhibitory mechanism provides a level of regulation of cAMP-dependent signals integration (Legueux-Cajgfinger et al. 2023).