8.A.9.2.3
CD98hc, heavy chain of the heterodimeric CD998 (CG2791) amino acid transporter; involved in cell fusion, cell adhesion, TOR signalling, and amino acid transprot via LAT1 and LAT2 (see TC# 2.A.3.8.32) (Reynolds et al. 2009). CD98hc combines with one of six CD98lc proteins to regulate vascular smooth muscle cell proliferation in atherosclerosis (Baumer et al. 2017). CD98 heavy chain is a prognostic biomarker and target for cancer treatment (Xia and Dubrovska 2023). CD98hc promotes drug resistance in extranodal
natural killer/T cell lymphoma through tumor cell-derived small
extracellular vesicles (Liao et al. 2024).
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| Accession Number: | Q9VHX9 |
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| Protein Name: | CD98 heavy chain, isoform A |
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| Length: | 565 |
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| Molecular Weight: | 62677.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 1 |
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| Substrate |
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1: MVQDEKAAHA DGADEQMLGS NGVEDKLAER RDEVKFIKGD HQNGDAKIDI GTVNGGKPAF
61: TGMSKEELMK YANDPFWVRL RWIFFVCFWA IWVGMLVGAI LIIIGAPKCA APQPLPWYKR
121: GPHAKFASVE TCRPEDVQVA KKLVSAGAIY ELPAALTYDV KKPEVEEKIK HLVALYQGSD
181: TRVILDLTPN YAAKNSQLVQ DAIANPEKRS AFVWVSGGKA LPNNWLKVGG NRSAWEKVGD
241: NYVLSQFEDG YYDLKMNSTI IRNEFGAVLK HLVALGVRGF RLKNTKFFAL FDSLEDEQIS
301: SSPKDFSLGP NEYGFYSHRQ TTFLSGLGDV LYDYLSIVKN ASDEAFFSVA EDVMEPQVYQ
361: LSGDSGAYGI DLPMYGNFVK VLSKSKPDTS LQKELDNTLA QSGTDSWLQW NLADVYVDTP
421: QDPSALAMFL SLLPGVPVVA VDAVAYQNVT EETYRQITSL RKTASYMHGN LNLYQADPLV
481: AFSRIKSGNP GYFVIFNPTE LPQASNFTIP DNLPDKMTVS YFSEQYNNNM DNSGKVAHAG
541: RVNLKDLKVA PHSSIILTYV PVKAE