8.A.96.1.1
Mitochondrial TMEM70 with 260 aas and 2 (or 3) TMSs. Involved in F-type ATPase biogenesis in higher eukaryotes (Houstek et al. 2009). TMEM70 downregulation downregulated the mitochondrial ATPase, ATPB, but upregulated glycolysis-related glucose transporter member 1 (GLUT1) and glucose-6-phosphate dehydrogenase, suggesting a metabolic shift from oxidative phosphorylation to glycolysis, known as the Warburg effect (Mizukami et al. 2017).
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| Accession Number: | Q9BUB7 |
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| Protein Name: | Transmembrane protein 70, mitochondrial |
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| Length: | 260 |
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| Molecular Weight: | 28969.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MLFLALGSPW AVELPLCGRR TALCAAAALR GPRASVSRAS SSSGPSGPVA GWSTGPSGAA
61: RLLRRPGRAQ IPVYWEGYVR FLNTPSDKSE DGRLIYTGNM ARAVFGVKCF SYSTSLIGLT
121: FLPYIFTQNN AISESVPLPI QIIFYGIMGS FTVITPVLLH FITKGYVIRL YHEATTDTYK
181: AITYNAMLAE TSTVFHQNDV KIPDAKHVFT TFYAKTKSLL VNPVLFPNRE DYIHLMGYDK
241: EEFILYMEET SEEKRHKDDK