8.B.28.1.8
Iota-conotoxin of 69 aas and 1 N-terminal TMS. Iota-conotoxins bind to voltage-gated sodium
channels and act as agonists by shifting the voltage-dependence of
activation to more hyperpolarized levels. This toxin enhances
tetrodotoxin-sensitive sodium current in rat dorsal root ganglion
neurons (Wang et al. 2009).
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| Accession Number: | Q2I2Q5 |
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| Protein Name: | Iota-conotoxin LtIIIA |
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| Length: | 69 |
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| Molecular Weight: | 7931.00 |
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| Species: | Conus litteratus (Lettered cone) [89445] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
|
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1: MLKMGVLLFT FLVLFPLTTL ELDTDRPVER HAAIKQDLKP QERRGIRLHA PRDECCEPQW
61: CDGACDCCS