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8.B.28.1.8
Iota-conotoxin of 69 aas and 1 N-terminal TMS. Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin enhances tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons (Wang et al. 2009).

Accession Number:Q2I2Q5
Protein Name:Iota-conotoxin LtIIIA
Length:69
Molecular Weight:7931.00
Species:Conus litteratus (Lettered cone) [89445]
Location1 / Topology2 / Orientation3: Secreted1
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLKMGVLLFT FLVLFPLTTL ELDTDRPVER HAAIKQDLKP QERRGIRLHA PRDECCEPQW 
61:	CDGACDCCS