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|---|---|
| Accession Number: | P30968 |
| Protein Name: | Gonadotropin-releasing hormone receptor |
| Length: | 328 |
| Molecular Weight: | 37731.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 7 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | |
Cross database links:
| Entrez Gene ID: | 2798 |
|---|---|
| Pfam: | PF00001 |
| KEGG: | hsa:2798 hsa:2798 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0004968
F:gonadotropin-releasing hormone receptor activity
GO:0007275
P:multicellular organismal development
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References (34)[1] “Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor.” Kakar S.S.et.al. 1333190 [2] “Cloning and characterization of the human GnRH receptor.” Chi L.et.al. 8386108 [3] “The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary.” Kakar S.S.et.al. 7534732 [4] “Molecular structure of the human gonadotropin-releasing hormone receptor gene.” Kakar S.S.et.al. 9272108 [5] “Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor.” Grosse R.et.al. 9259321 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene.” Kottler M.L.et.al. 10366411 [8] “A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor.” de Roux N.et.al. 9371856 [9] “Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism.” Layman L.C.et.al. 9425890 [10] “The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred.” de Roux N.et.al. 10022417 [11] “Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration.” Caron P.et.al. 10084584 [12] “Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor.” Pralong F.P.et.al. 10523035 [13] “The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor.” Pitteloud N.et.al. 11397842 [14] “A novel homozygous mutation in the second transmembrane domain of the gonadotrophin releasing hormone receptor gene.” Soederlund D.et.al. 11318785 [15] “Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction.” Costa E.M.F.et.al. 11397871 [16] “Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site.” Maya-Nunez G.et.al. 11994356 [17] “Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism.” Karges B.et.al. 12679486 [18] “Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor.” Kakar S.S.et.al. 1333190 [19] “Cloning and characterization of the human GnRH receptor.” Chi L.et.al. 8386108 [20] “The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary.” Kakar S.S.et.al. 7534732 [21] “Molecular structure of the human gonadotropin-releasing hormone receptor gene.” Kakar S.S.et.al. 9272108 [22] “Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor.” Grosse R.et.al. 9259321 [23] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [24] “Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene.” Kottler M.L.et.al. 10366411 [25] “A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor.” de Roux N.et.al. 9371856 [26] “Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism.” Layman L.C.et.al. 9425890 [27] “The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred.” de Roux N.et.al. 10022417 [28] “Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration.” Caron P.et.al. 10084584 [29] “Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor.” Pralong F.P.et.al. 10523035 [30] “The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor.” Pitteloud N.et.al. 11397842 [31] “A novel homozygous mutation in the second transmembrane domain of the gonadotrophin releasing hormone receptor gene.” Soederlund D.et.al. 11318785 [32] “Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction.” Costa E.M.F.et.al. 11397871 [33] “Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site.” Maya-Nunez G.et.al. 11994356 [34] “Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism.” Karges B.et.al. 12679486
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MANSASPEQN QNHCSAINNS IPLMQGNLPT LTLSGKIRVT VTFFLFLLSA TFNASFLLKL 61: QKWTQKKEKG KKLSRMKLLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG ELLCKVLSYL 121: KLFSMYAPAF MMVVISLDRS LAITRPLALK SNSKVGQSMV GLAWILSSVF AGPQLYIFRM 181: IHLADSSGQT KVFSQCVTHC SFSQWWHQAF YNFFTFSCLF IIPLFIMLIC NAKIIFTLTR 241: VLHQDPHELQ LNQSKNNIPR ARLKTLKMTV AFATSFTVCW TPYYVLGIWY WFDPEMLNRL 301: SDPVNHFFFL FAFLNPCFDP LIYGYFSL