9.A.14.13.21
Prorelaxin receptor RXFP3 (RLN3R1, SALPR) of 469 aas and 7 TMSs. Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Cholesterol modulates the binding properties of human RXFP3 with its ligands, enhancing that of some, and decreasing that of others (Wang et al. 2018).
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| Accession Number: | Q9NSD7 |
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| Protein Name: | Relaxin-3 receptor 1 |
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| Length: | 469 |
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| Molecular Weight: | 51124.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MQMADAATIA TMNKAAGGDK LAELFSLVPD LLEAANTSGN ASLQLPDLWW ELGLELPDGA
61: PPGHPPGSGG AESADTEARV RILISVVYWV VCALGLAGNL LVLYLMKSMQ GWRKSSINLF
121: VTNLALTDFQ FVLTLPFWAV ENALDFKWPF GKAMCKIVSM VTSMNMYASV FFLTAMSVTR
181: YHSVASALKS HRTRGHGRGD CCGRSLGDSC CFSAKALCVW IWALAALASL PSAIFSTTVK
241: VMGEELCLVR FPDKLLGRDR QFWLGLYHSQ KVLLGFVLPL GIIILCYLLL VRFIADRRAA
301: GTKGGAAVAG GRPTGASARR LSKVTKSVTI VVLSFFLCWL PNQALTTWSI LIKFNAVPFS
361: QEYFLCQVYA FPVSVCLAHS NSCLNPVLYC LVRREFRKAL KSLLWRIASP SITSMRPFTA
421: TTKPEHEDQG LQAPAPPHAA AEPDLLYYPP GVVVYSGGRY DLLPSSSAY