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|---|---|
| Accession Number: | Q99705 |
| Protein Name: | Melanin-concentrating hormone receptor 1 |
| Length: | 422 |
| Molecular Weight: | 45963.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 7 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | |
Cross database links:
| Entrez Gene ID: | 2847 |
|---|---|
| Pfam: | PF00001 |
| KEGG: | hsa:2847 hsa:2847 hsa:2847 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0031513
C:nonmotile primary cilium
GO:0008188
F:neuropeptide receptor activity
GO:0007204
P:elevation of cytosolic calcium ion concentration
GO:0007631
P:feeding behavior
GO:0006091
P:generation of precursor metabolites and energy
GO:0007193
P:inhibition of adenylate cyclase activity by G-protein signaling pathway
GO:0042562
F:hormone binding
GO:0030273
F:melanin-concentrating hormone receptor activity
GO:0007193
P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0051928
P:positive regulation of calcium ion transport
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References (33)[1] “Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.” Shimomura Y.et.al. 10441476 [2] “Mutation analysis of the MCHR1 gene in human obesity.” Wermter A.-K.et.al. 15941924 [3] “A genome annotation-driven approach to cloning the human ORFeome.” Collins J.E.et.al. 15461802 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “The DNA sequence of human chromosome 22.” Dunham I.et.al. 10591208 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Characterization of a human gene related to genes encoding somatostatin receptors.” Kolakowski L.F. Jr.et.al. 8977118 [8] “Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.” Chambers J.et.al. 10421367 [9] “Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.” Francke F.et.al. 16945926 [10] “Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.” Gibson W.T.et.al. 15166293 [11] “Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.” Hawes B.E.et.al. 15340116 [12] “Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.” Shimomura Y.et.al. 10441476 [13] “Mutation analysis of the MCHR1 gene in human obesity.” Wermter A.-K.et.al. 15941924 [14] “A genome annotation-driven approach to cloning the human ORFeome.” Collins J.E.et.al. 15461802 [15] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [16] “The DNA sequence of human chromosome 22.” Dunham I.et.al. 10591208 [17] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [18] “Characterization of a human gene related to genes encoding somatostatin receptors.” Kolakowski L.F. Jr.et.al. 8977118 [19] “Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.” Chambers J.et.al. 10421367 [20] “Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.” Francke F.et.al. 16945926 [21] “Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.” Gibson W.T.et.al. 15166293 [22] “Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.” Hawes B.E.et.al. 15340116 [23] “Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.” Shimomura Y.et.al. 10441476 [24] “Mutation analysis of the MCHR1 gene in human obesity.” Wermter A.-K.et.al. 15941924 [25] “A genome annotation-driven approach to cloning the human ORFeome.” Collins J.E.et.al. 15461802 [26] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [27] “The DNA sequence of human chromosome 22.” Dunham I.et.al. 10591208 [28] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [29] “Characterization of a human gene related to genes encoding somatostatin receptors.” Kolakowski L.F. Jr.et.al. 8977118 [30] “Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.” Chambers J.et.al. 10421367 [31] “Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.” Francke F.et.al. 16945926 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP AWVEGSSARL 61: WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP RTGSISYINI IMPSVFGTIC 121: LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF IINLSVVDLL FLLGMPFMIH QLMGNGVWHF 181: GETMCTLITA MDANSQFTST YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS 241: FISITPVWLY ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI 301: LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS ISRPTLTFVY 361: LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ GQLRAVSNAQ TADEERTESK 421: GT