TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.14.15.1
Gamma-aminobutyric acid type B receptor subunit 2

Accession Number:O75899
Protein Name:Gamma-aminobutyric acid type B receptor subunit 2
Length:941
Molecular Weight:105821.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Entrez Gene ID: 9568   
Pfam: PF00003    PF01094   
KEGG: hsa:9568    hsa:9568   

Gene Ontology

GO:0030054 C:cell junction
GO:0005887 C:integral to plasma membrane
GO:0045211 C:postsynaptic membrane
GO:0004965 F:G-protein coupled GABA receptor activity
GO:0007194 P:negative regulation of adenylate cyclase activity
GO:0007268 P:synaptic transmission

References (18)

[1] “Heterodimerization is required for the formation of a functional GABA(B) receptor.”  White J.H.et.al.   9872316
[2] “Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9.”  Ng G.Y.K.et.al.   10087195
[3] “Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1.”  Martin S.C.et.al.   10328880
[4] “Distribution of the GABA(B) receptor subunit gb2 in rat CNS.”  Clark J.A.et.al.   10727622
[5] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.”  Ng G.Y.K.et.al.   10075644
[8] “Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.”  Sullivan R.et.al.   10773016
[9] “Phosphoproteomic analysis of synaptosomes from human cerebral cortex.”  DeGiorgis J.A.et.al.   15822905
[10] “Heterodimerization is required for the formation of a functional GABA(B) receptor.”  White J.H.et.al.   9872316
[11] “Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9.”  Ng G.Y.K.et.al.   10087195
[12] “Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1.”  Martin S.C.et.al.   10328880
[13] “Distribution of the GABA(B) receptor subunit gb2 in rat CNS.”  Clark J.A.et.al.   10727622
[14] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[16] “Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.”  Ng G.Y.K.et.al.   10075644
[17] “Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.”  Sullivan R.et.al.   10773016
[18] “Phosphoproteomic analysis of synaptosomes from human cerebral cortex.”  DeGiorgis J.A.et.al.   15822905
Structure:
4F11   4F12   4MQE   4MQF   4MR7   4MR8   4MR9   4MRM   4MS1   4MS3   [...more]

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MASPRSSGQP GPPPPPPPPP ARLLLLLLLP LLLPLAPGAW GWARGAPRPP PSSPPLSIMG 
61:	LMPLTKEVAK GSIGRGVLPA VELAIEQIRN ESLLRPYFLD LRLYDTECDN AKGLKAFYDA 
121:	IKYGPNHLMV FGGVCPSVTS IIAESLQGWN LVQLSFAATT PVLADKKKYP YFFRTVPSDN 
181:	AVNPAILKLL KHYQWKRVGT LTQDVQRFSE VRNDLTGVLY GEDIEISDTE SFSNDPCTSV 
241:	KKLKGNDVRI ILGQFDQNMA AKVFCCAYEE NMYGSKYQWI IPGWYEPSWW EQVHTEANSS 
301:	RCLRKNLLAA MEGYIGVDFE PLSSKQIKTI SGKTPQQYER EYNNKRSGVG PSKFHGYAYD 
361:	GIWVIAKTLQ RAMETLHASS RHQRIQDFNY TDHTLGRIIL NAMNETNFFG VTGQVVFRNG 
421:	ERMGTIKFTQ FQDSREVKVG EYNAVADTLE IINDTIRFQG SEPPKDKTII LEQLRKISLP 
481:	LYSILSALTI LGMIMASAFL FFNIKNRNQK LIKMSSPYMN NLIILGGMLS YASIFLFGLD 
541:	GSFVSEKTFE TLCTVRTWIL TVGYTTAFGA MFAKTWRVHA IFKNVKMKKK IIKDQKLLVI 
601:	VGGMLLIDLC ILICWQAVDP LRRTVEKYSM EPDPAGRDIS IRPLLEHCEN THMTIWLGIV 
661:	YAYKGLLMLF GCFLAWETRN VSIPALNDSK YIGMSVYNVG IMCIIGAAVS FLTRDQPNVQ 
721:	FCIVALVIIF CSTITLCLVF VPKLITLRTN PDAATQNRRF QFTQNQKKED SKTSTSVTSV 
781:	NQASTSRLEG LQSENHRLRM KITELDKDLE EVTMQLQDTP EKTTYIKQNH YQELNDILNL 
841:	GNFTESTDGG KAILKNHLDQ NPQLQWNTTE PSRTCKDPIE DINSPEHIQR RLSLQLPILH 
901:	HAYLPSIGGV DASCVSPCVS PTASPRHRHV PPSFRVMVSG L