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| Accession Number: | O75899 |
| Protein Name: | Gamma-aminobutyric acid type B receptor subunit 2 |
| Length: | 941 |
| Molecular Weight: | 105821.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 8 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | |
Cross database links:
| Entrez Gene ID: | 9568 |
|---|---|
| Pfam: | PF00003 PF01094 |
| KEGG: | hsa:9568 hsa:9568 |
Gene Ontology
GO:0030054
C:cell junction
GO:0005887
C:integral to plasma membrane
GO:0045211
C:postsynaptic membrane
GO:0004965
F:G-protein coupled GABA receptor activity
GO:0007194
P:negative regulation of adenylate cyclase activity
GO:0007268
P:synaptic transmission
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References (18)[1] “Heterodimerization is required for the formation of a functional GABA(B) receptor.” White J.H.et.al. 9872316 [2] “Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9.” Ng G.Y.K.et.al. 10087195 [3] “Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1.” Martin S.C.et.al. 10328880 [4] “Distribution of the GABA(B) receptor subunit gb2 in rat CNS.” Clark J.A.et.al. 10727622 [5] “DNA sequence and analysis of human chromosome 9.” Humphray S.J.et.al. 15164053 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.” Ng G.Y.K.et.al. 10075644 [8] “Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.” Sullivan R.et.al. 10773016 [9] “Phosphoproteomic analysis of synaptosomes from human cerebral cortex.” DeGiorgis J.A.et.al. 15822905 [10] “Heterodimerization is required for the formation of a functional GABA(B) receptor.” White J.H.et.al. 9872316 [11] “Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9.” Ng G.Y.K.et.al. 10087195 [12] “Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1.” Martin S.C.et.al. 10328880 [13] “Distribution of the GABA(B) receptor subunit gb2 in rat CNS.” Clark J.A.et.al. 10727622 [14] “DNA sequence and analysis of human chromosome 9.” Humphray S.J.et.al. 15164053 [15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [16] “Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.” Ng G.Y.K.et.al. 10075644 [17] “Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.” Sullivan R.et.al. 10773016 [18] “Phosphoproteomic analysis of synaptosomes from human cerebral cortex.” DeGiorgis J.A.et.al. 15822905
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| Structure: | |
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| FASTA formatted sequence |
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1: MASPRSSGQP GPPPPPPPPP ARLLLLLLLP LLLPLAPGAW GWARGAPRPP PSSPPLSIMG 61: LMPLTKEVAK GSIGRGVLPA VELAIEQIRN ESLLRPYFLD LRLYDTECDN AKGLKAFYDA 121: IKYGPNHLMV FGGVCPSVTS IIAESLQGWN LVQLSFAATT PVLADKKKYP YFFRTVPSDN 181: AVNPAILKLL KHYQWKRVGT LTQDVQRFSE VRNDLTGVLY GEDIEISDTE SFSNDPCTSV 241: KKLKGNDVRI ILGQFDQNMA AKVFCCAYEE NMYGSKYQWI IPGWYEPSWW EQVHTEANSS 301: RCLRKNLLAA MEGYIGVDFE PLSSKQIKTI SGKTPQQYER EYNNKRSGVG PSKFHGYAYD 361: GIWVIAKTLQ RAMETLHASS RHQRIQDFNY TDHTLGRIIL NAMNETNFFG VTGQVVFRNG 421: ERMGTIKFTQ FQDSREVKVG EYNAVADTLE IINDTIRFQG SEPPKDKTII LEQLRKISLP 481: LYSILSALTI LGMIMASAFL FFNIKNRNQK LIKMSSPYMN NLIILGGMLS YASIFLFGLD 541: GSFVSEKTFE TLCTVRTWIL TVGYTTAFGA MFAKTWRVHA IFKNVKMKKK IIKDQKLLVI 601: VGGMLLIDLC ILICWQAVDP LRRTVEKYSM EPDPAGRDIS IRPLLEHCEN THMTIWLGIV 661: YAYKGLLMLF GCFLAWETRN VSIPALNDSK YIGMSVYNVG IMCIIGAAVS FLTRDQPNVQ 721: FCIVALVIIF CSTITLCLVF VPKLITLRTN PDAATQNRRF QFTQNQKKED SKTSTSVTSV 781: NQASTSRLEG LQSENHRLRM KITELDKDLE EVTMQLQDTP EKTTYIKQNH YQELNDILNL 841: GNFTESTDGG KAILKNHLDQ NPQLQWNTTE PSRTCKDPIE DINSPEHIQR RLSLQLPILH 901: HAYLPSIGGV DASCVSPCVS PTASPRHRHV PPSFRVMVSG L