Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.16.1.1
Lysosomal-associated membrane glycoprotein-1 precursor, LAMP-1 (stabilizes TAPL (TC# 3.A.1.209.2) (Demirel et al., 2012). Human LAMP1 accelerates Lassa virus fusion and potently promotes fusion pore dilation upon forcing viral fusion with non-endosomal membrane (Zhang et al. 2022). Ectopic expression of hLAMP1 accelerated the kinetics of small fusion pore formation.  The Ykt6-Snap29-Syx13 SNARE complex promotes crinophagy via secretory granule fusion with Lamp1 carrier vesicles (Szenci et al. 2024).  The acidic pH of lysosomes is critical for catabolism in eukaryotic cells and is altered in neurodegenerative disease including Alzheimer's and Parkinson's. Reports using Drosophila and mammalian cell cultures have identified novel and, at first sight, conflicting roles for the lysosomal associated membrane proteins (LAMPs) in the regulation of the endolysosomal system (Handy et al. 2024). 

Accession Number:P11279
Protein Name:Lysosome-associated membrane glycoprotein 1
Length:417
Molecular Weight:44882.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 3916   
Pfam: PF01299   
KEGG: hsa:3916   

Gene Ontology

GO:0030425 C:dendrite
GO:0010008 C:endosome membrane
GO:0009897 C:external side of plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0042599 C:lamellar body
GO:0005770 C:late endosome
GO:0005765 C:lysosomal membrane
GO:0005764 C:lysosome
GO:0042470 C:melanosome
GO:0005624 C:membrane fraction
GO:0005771 C:multivesicular body
GO:0043025 C:neuronal cell body
GO:0042383 C:sarcolemma
GO:0048102 P:autophagic cell death
GO:0006914 P:autophagy

References (15)

[1] “Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.”  Fukuda M.et.al.   3198605
[2] “The DNA sequence and analysis of human chromosome 13.”  Dunham A.et.al.   15057823
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Purification and characterization of human lysosomal membrane glycoproteins.”  Mane S.M.et.al.   2912382
[5] “Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000.”  Viitala J.et.al.   3131762
[6] “The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.”  Sawada R.et.al.   8517882
[7] “Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement.”  Carlsson S.R.et.al.   2584229
[8] “The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.”  Carlsson S.R.et.al.   2243102
[9] “Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.”  Carlsson S.R.et.al.   8323299
[10] “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.”  Zhang H.et.al.   12754519
[11] “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.”  Liu T.et.al.   16335952
[12] “The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.”  Johansson M.et.al.   16176980
[13] “Integral and associated lysosomal membrane proteins.”  Schroeder B.et.al.   17897319
[14] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[15] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF SVNYDTKSGP 
61:	KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL TLNFTRNATR YSVQLMSFVY 
121:	NLSDTHLFPN ASSKEIKTVE SITDIRADID KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS 
181:	NSSFSRGETR CEQDRPSPTT APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL 
241:	NLTYERKDNT TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF 
301:	LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF SVNIFKVWVQ 
361:	AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL IAYLVGRKRS HAGYQTI