9.A.16.1.9
Lysosome-associated membrane glycoprotein 3. LAMP3, of 416 aas and 2 TMSs, N- and C-terminal.   It plays a role in the unfolded protein response that contributes to protein degradation and cell survival during proteasomal dysfunction (Dominguez-Bautista et al. 2015). It plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (Nagelkerke et al. 2014). It supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F (Ueo et al. 2020). It also plays a positive role in post-entry steps of influenza A virus replication (Zhou et al. 2011), and it promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection while promoting the intracellular proliferation of Salmonella typhimuium.(Ueo et al. 2020).