9.A.28.1.1
The ethanolamine facilitator EutH, of 408 aas and 11 or 12 TMSs. The E. coli orthologue (P76552) is identical to the S. enterica protein. They are probably involved in the diffusion of protonated
ethanolamine (EA) into the cell at low pH where most EA is
protonated, and this permease becomes necessary. It contributes
to bacterial survival and replication in acidified macrophage vacuoles (Anderson et al. 2018). It is associated with a bacterial ethanol metabolizing bacteria microcompartment, Eut1 (Kirst and Kerfeld 2021).
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| Accession Number: | P41796 |
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| Protein Name: | Ethanolamine utilization protein eutH aka Putative ethanolamine transporter |
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| Length: | 408 |
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| Molecular Weight: | 42827.00 |
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| Species: | Salmonella typhimurium [90371] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ethanolamine |
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| RefSeq: |
NP_461395.1
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| Entrez Gene ID: |
1253982
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| Pfam: |
PF04346
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| BioCyc: |
STYP99287:STM2460-MONOMER
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| KEGG: |
stm:STM2460
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[1] “Ethanolamine utilization in Salmonella typhimurium: nucleotide sequence, protein expression, and mutational analysis of the cchA cchB eutE eutJ eutG eutH gene cluster.” Stojiljkovic I. et.al. 7868611
[2] “The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins.” Kofoid E.C. et.al. 10464203
[3] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.” McClelland M. et.al. 11677609
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1: MGINEIIMYI MMFFMLIAAV DRILSQFGGS ARFLGKFGKS IEGSGGQFEE GFMAMGALGL
61: AMVGMTALAP VLAHVLGPVI IPVYEMLGAN PSMFAGTLLA CDMGGFFLAK ELAGGDVAAW
121: LYSGLILGSM MGPTIVFSIP VALGIIEPSD RRYLALGVLA GIVTIPIGCI AGGLIAMYSG
181: VQINGQPVEF TFALILMNMI PVLIVAVLVA LGLKFIPEKM INGFQIFAKF LVALITIGLA
241: AAVVKFLLGW ELIPGLDPIF MAPGDKPGEV MRAIEVIGSI SCVLLGAYPM VLLLTRWFEK
301: PLMNVGKLLN VNNIAAAGMV ATLANNIPMF GMMKQMDTRG KVINCAFAVS AAFALGDHLG
361: FAAANMNAMI FPMIVGKLIG GVTAIGVAMM LVPKDDAAQV KTEAEAQS