9.A.57.1.1
Extended synaptotagmin T1, EsyT1, of 1104 aas and 2 TMSs. The protein has two C2 domains, C2A and C2B, which interact with numberous proteins individually or together. These include those involved in synaptic transmission, metabolic regulation and transport (Guo et al. 2017). It binds glycerophospholipids in a barrel-like domain
and may play a role in cellular lipid transport. It also binds
calcium (via the C2 domains) and translocates to sites of contact
between the endoplasmic reticulum (ER) and the cell membrane in response to
increased cytosolic calcium levels (Chang et al. 2013). It helps tether the ER to the cell membrane and promotes the formation of appositions
between the ER and the cell membrane. See family description for more details and references. ESYT1 tethers the ER to mitochondria via mitochondria-ER contact sites (MERCs), and is required for mitochondrial lipid and calcium homeostasis (Janer et al. 2024). Thus, ESYT1 plays a role in mitochondrial and cellular homeostasis through its role in the regulation of MERCs.
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| Accession Number: | Q9BSJ8 |
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| Protein Name: | Extended synaptotagmin-1 |
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| Length: | 1104 |
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| Molecular Weight: | 122856.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
lipid |
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1: MERSPGEGPS PSPMDQPSAP SDPTDQPPAA HAKPDPGSGG QPAGPGAAGE ALAVLTSFGR
61: RLLVLIPVYL AGAVGLSVGF VLFGLALYLG WRRVRDEKER SLRAARQLLD DEEQLTAKTL
121: YMSHRELPAW VSFPDVEKAE WLNKIVAQVW PFLGQYMEKL LAETVAPAVR GSNPHLQTFT
181: FTRVELGEKP LRIIGVKVHP GQRKEQILLD LNISYVGDVQ IDVEVKKYFC KAGVKGMQLH
241: GVLRVILEPL IGDLPFVGAV SMFFIRRPTL DINWTGMTNL LDIPGLSSLS DTMIMDSIAA
301: FLVLPNRLLV PLVPDLQDVA QLRSPLPRGI IRIHLLAARG LSSKDKYVKG LIEGKSDPYA
361: LVRLGTQTFC SRVIDEELNP QWGETYEVMV HEVPGQEIEV EVFDKDPDKD DFLGRMKLDV
421: GKVLQASVLD DWFPLQGGQG QVHLRLEWLS LLSDAEKLEQ VLQWNWGVSS RPDPPSAAIL
481: VVYLDRAQDL PLKKGNKEPN PMVQLSIQDV TQESKAVYST NCPVWEEAFR FFLQDPQSQE
541: LDVQVKDDSR ALTLGALTLP LARLLTAPEL ILDQWFQLSS SGPNSRLYMK LVMRILYLDS
601: SEICFPTVPG CPGAWDVDSE NPQRGSSVDA PPRPCHTTPD SQFGTEHVLR IHVLEAQDLI
661: AKDRFLGGLV KGKSDPYVKL KLAGRSFRSH VVREDLNPRW NEVFEVIVTS VPGQELEVEV
721: FDKDLDKDDF LGRCKVRLTT VLNSGFLDEW LTLEDVPSGR LHLRLERLTP RPTAAELEEV
781: LQVNSLIQTQ KSAELAAALL SIYMERAEDL PLRKGTKHLS PYATLTVGDS SHKTKTISQT
841: SAPVWDESAS FLIRKPHTES LELQVRGEGT GVLGSLSLPL SELLVADQLC LDRWFTLSSG
901: QGQVLLRAQL GILVSQHSGV EAHSHSYSHS SSSLSEEPEL SGGPPHITSS APELRQRLTH
961: VDSPLEAPAG PLGQVKLTLW YYSEERKLVS IVHGCRSLRQ NGRDPPDPYV SLLLLPDKNR
1021: GTKRRTSQKK RTLSPEFNER FEWELPLDEA QRRKLDVSVK SNSSFMSRER ELLGKVQLDL
1081: AETDLSQGVA RWYDLMDNKD KGSS