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|---|---|
| Accession Number: | Q12142 |
| Protein Name: | Autophagy-related protein 9 |
| Length: | 997 |
| Molecular Weight: | 115403.00 |
| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
| Number of TMSs: | 6 |
| Location1 / Topology2 / Orientation3: | Preautophagosomal structure membrane1 / Multi-pass membrane protein2 |
| Substrate | phospholipid, phosphatidylcholine(1+), phosphatidyl-L-serine, phosphatidylinositol 4-phosphate |
Cross database links:
| DIP: | DIP-1938N DIP-1938N DIP-1938N DIP-1938N DIP-1938N |
|---|---|
| Entrez Gene ID: | 851406 |
| Pfam: | PF04109 |
| KEGG: | sce:YDL149W |
Gene Ontology
GO:0030659
C:cytoplasmic vesicle membrane
GO:0016021
C:integral to membrane
GO:0005624
C:membrane fraction
GO:0005739
C:mitochondrion
GO:0034045
C:pre-autophagosomal structure membrane
GO:0000045
P:autophagic vacuole assembly
GO:0032258
P:CVT pathway
GO:0000422
P:mitochondrion degradation
GO:0034727
P:piecemeal microautophagy of nucleus
GO:0051260
P:protein homooligomerization
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References (19)[1] “Analysis of a 23 kb region on the left arm of yeast chromosome IV.” Delaveau T.T.D.et.al. 8972581 [2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.” Jacq C.et.al. 9169867 [3] “Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.” Tsukada M.et.al. 8224160 [4] “Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway.” Harding T.M.et.al. 7593182 [5] “Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway.” Harding T.M.et.al. 8663607 [6] “Autophagy and the cvt pathway both depend on AUT9.” Lang T.et.al. 10735854 [7] “Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways.” Noda T.et.al. 10662773 [8] “The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.” Suzuki K.et.al. 11689437 [9] “Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways.” Wang C.-W.et.al. 11382760 [10] “A unified nomenclature for yeast autophagy-related genes.” Klionsky D.J.et.al. 14536056 [11] “Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy.” Tucker K.A.et.al. 14504273 [12] “The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure.” Reggiori F.et.al. 14723849 [13] “Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts.” Reggiori F.et.al. 16874040 [14] “Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast.” He C.et.al. 17178909 [15] “A global topology map of the Saccharomyces cerevisiae membrane proteome.” Kim H.et.al. 16847258 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MERDEYQLPN SHGKNTFLSR IFGLQSDEVN PSLNSQEMSN FPLPDIERGS SLLHSTNDSR 61: EDVDENDLRV PESDQGTSTE EEDEVDEEQV QAYAPQISDG LDGDHQLNSV TSKENVLETE 121: KSNLERLVEG STDDSVPKVG QLSSEEEEDN EFINNDGFDD DTPLFQKSKI HEFSSKKSNT 181: IEDGKRPLFF RHILQNNRPQ RDTQKLFTSS NAIHHDKDKS ANNGPRNING NQKHGTKYFG 241: SATQPRFTGS PLNNTNRFTK LFPLRKPNLL SNISVLNNTP EDRINTLSVK ERALWKWANV 301: ENLDIFLQDV YNYYLGNGFY CIILEKILNI CTLLFVVFVS TYMGHCVDYS KLPTSHRVSD 361: IIIDKCYSNS ITGFTKFFLW MFYFFVILKI VQLYFDVQKL SELQNFYKYL LNISDDELQT 421: LPWQNVIQQL MYLKDQNAMT ANVVEVKAKN RIDAHDVANR IMRRENYLIA LYNSDILNLS 481: LPIPLFRTNV LTKTLEWNIN LCVMGFVFNE SGFIKQSILK PSQREFTREE LQKRFMLAGF 541: LNIILAPFLV TYFVLLYFFR YFNEYKTSPG SIGARQYTPI AEWKFREYNE LYHIFKKRIS 601: LSTTLANKYV DQFPKEKTNL FLKFVSFICG SFVAILAFLT VFDPENFLNF EITSDRSVIF 661: YITILGAIWS VSRNTITQEY HVFDPEETLK ELYEYTHYLP KEWEGRYHKE EIKLEFCKLY 721: NLRIVILLRE LTSLMITPFV LWFSLPSSAG RIVDFFRENS EYVDGLGYVC KYAMFNMKNI 781: DGEDTHSMDE DSLTKKIAVN GSHTLNSKRR SKFTAEDHSD KDLANNKMLQ SYVYFMDDYS 841: NSENLTGKYQ LPAKKGYPNN EGDSFLNNKY SWRKQFQPGQ KPELFRIGKH ALGPGHNISP 901: AIYSTRNPGK NWDNNNNGDD IKNGTNNATA KNDDNNGNND HEYVLTESFL DSGAFPNHDV 961: IDHNKMLNSN YNGNGILNKG GVLGLVKEYY KKSDVGR