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9.B.13 The Putative Pore-forming Entericidin (ECN) Family

&9;The ECN family includes two small lipoproteins, Entericidin B (a bacteriolytic toxin; 27 amino acyl residues) and Entericidin A (an anti-toxin antibiotic; 23 residues) in which the amino terminal cysteine is derivatized with an N-acyl-S-sn-1,2 diacyl glyceryl moiety. Both lipoproteins are predicted to adopt amphipathic α-helical structures in phospholipid bilayers and to thereby modulate membrane stability. These two small lipoproteins are tandemly encoded in the ecn locus of the E. coli chromosome; their syntheses are induced in stationary phase, and they mediate programmed cell death of a subpopulation of the bacteria. It is possible that Entericidin B exerts its toxic effect by forming transmembrane pores, but this possibility has not been established.

References associated with 9.B.13 family:

Bishop, R.E., S.S. Penfold, L.S. Frost, J.V. Holtje, J.H. Weiner (1995). Stationary phase expression of a novel Escherichia coli outer membrane lipoprotein and its relationship with mammalian Apolipoprotein D - implications for the origin of lipocalins. J. Biol. Chem. 270:23097-23103. 7559452
Bishop, R.E., B.K. Leskiw, R.S. Hodges, C.M. Kay and J.H. Weiner (1998). The entericidin locus of Escherichia coli and its implications for programmed bacterial cell death. J. Mol. Biol. 280: 583-596. 9677290