9.B.130.1.4
Synaptophysin (Syp), of 313 aas and 4 TMSs, functions in synaptic vesicle cycling, endocytosis, and synaptic
plasticity, and plays a role in the process of membrane fusion during Ca2+-triggered exocytosis and catecholamine release from single vesicles of chromaffin cells. See family description (Chang et al. 2021). Synaptophysin transmembrane domain III controls fusion pore dynamics during Ca2+-triggered exocytosis (Hsiao and Jackson 2022).
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| Accession Number: | P08247 |
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| Protein Name: | Synaptophysin |
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| Length: | 313 |
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| Molecular Weight: | 33845.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasmic vesicle1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MLLLADMDVV NQLVAGGQFR VVKEPLGFVK VLQWVFAIFA FATCGSYSGE LQLSVDCANK
61: TESDLSIEVE FEYPFRLHQV YFDAPTCRGG TTKVFLVGDY SSSAEFFVTV AVFAFLYSMG
121: ALATYIFLQN KYRENNKGPM LDFLATAVFA FMWLVSSSAW AKGLSDVKMA TDPENIIKEM
181: PVCRQTGNTC KELRDPVTSG LNTSVVFGFL NLVLWVGNLW FVFKETGWAA PFLRAPPGAP
241: EKQPAPGDAY GDAGYGQGPG GYGPQDSYGP QGGYQPDYGQ PAGSGGSGYG PQGDYGQQGY
301: GPQGAPTSFS NQM