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9.B.131  The Post-GPI Attachment Protein (P-GAP2) Family

Glycosylphosphatidylinositol (GPI) is a complex glycolipid that serves as a membrane anchor for many cell-surface proteins, such as Thy-1 and CD48. GPI-anchored proteins (GPI-APs) play important roles in many biological processes, such as signal transduction and cell-cell interaction, through their association with lipid rafts. Fatty acid remodeling of GPI-APs in the Golgi apparatus is required for their efficient association with lipid rafts, i.e., the unsaturated fatty acid at the sn-2 position of the PI moiety is exchanged for the saturated fatty acid by PGAP2 and PGAP3 (Murakami et al., 2012).

References associated with 9.B.131 family:

Murakami, H., Y. Wang, H. Hasuwa, Y. Maeda, T. Kinoshita, and Y. Murakami. (2012). Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins. Biochem. Biophys. Res. Commun. 417: 1235-1241. 22227195
Nakazawa, N., X. Xu, O. Arakawa, and M. Yanagida. (2019). Coordinated Roles of the Putative Ceramide-Conjugation Protein, Cwh43, and a Mn-Transporting, P-Type ATPase, Pmr1, in Fission Yeast. G3 (Bethesda) 9: 2667-2676. 31201205