| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
9.B.21.1.1 | Frataxin (Fxn; FrdA) of 210 aas. Defective in the inherited neuro- and cardio-degenerative disease, Friedreich's ataxia (FA), caused by the deficient expression of frataxin that leads to deleterious alterations in iron metabolism (Chiang et al. 2016). | Eukaryota |
Metazoa, Chordata | Frataxin of Homo sapiens (Q16595) |
|
9.B.21.1.2 | Frataxin homologue, Yfh1, of 174 aas. Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. It also plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+. It can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization and may be involved in the regulation of the mitochondrial electron transport chain (Karlberg et al. 2006). | Eukaryota |
Fungi, Ascomycota | Yfh1 of Saccharomyces cerevisiae (Baker's yeast) |
|
9.B.21.2.1 | The CyaY protein of 106 aas is an iron transport protein for iron-sulfur (Fe-S) cluster biosynthetic systems (Uchida et al. 2017). It also transports iron to ferrochelatase that catalyzes insertion of Fe2+ into protoporphyrin IX. Uchida et al. 2017 found that CyaY has the ability to bind heme as well as iron. | Bacteria |
Pseudomonadota | CyaY of E. coli (P27838) |