TCDB is operated by the Saier Lab Bioinformatics Group

9.B.275.  The Phosphoethanolamine Transferase (PEAT) Family

E. coli produces chemically modified cellulose that is required for extracellular matrix assembly and biofilm architecture. Solid-state NMR spectroscopy of the intact and insoluble material revealed a zwitterionic phosphoethanolamine modification. Insertioin of the phosphoethanolamine group requires BcsG, a phosphoethanolamine transferase, with biofilm-promoting cyclic diguanylate monophosphate input through a BcsE-BcsF-BcsG transmembrane signaling pathway. The bcsEFG operon is present in many bacteria, including Salmonella species, that also produce the modified cellulose.