9.B.308.3.2
ER movement protein p6 (6 kDa protein) (or ORF2) of 54 aas and 1 N-terminal TMS. Cell-to-cell movement of beet yellows closterovirus requires four structural proteins and the 6-kDa protein (p6). Either virus infection or p6 overexpression results in association of p6 with the rough endoplasmic reticulum. The p6 protein has a hydrophilic, C-terminal domain that is localized on the cytoplasmic face of the ER. In the infected cells, p6 forms a disulfide bridge via a cysteine residue located near the protein's N terminus. Mutagenic analyses indicated that each of the p6 domains, as well as protein dimerization, is essential for p6 function in virus movement (Peremyslov et al. 2004).