TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.36.1.1









The acid resistance 6 TMS HdeD protein of 190 aas. The yhiD and hdeD gene products participate in an acid resistance mechanism exhibited only at high cell densities (Mates et al. 2007). H-NS directly controls expression of the hedD gene (Krin et al. 2010).  Both small RNAs, CyaR and RprA, interact with the 5'-UTR of hdeD mRNA, and binding to the RBS of hdeD, interfers with translational initiation. Lalaouna et al. 2018 identified an A/U-rich motif on hdeD, which is bound by the RNA chaperone Hfq. The results indicate that binding of this motif by Hfq is required for CyaR-induced degradation of hdeD mRNA, and two molecules of RprA must bind the 5'-UTR of hdeD to block translation initiation. While both CyaR and RprA sRNAs bind to the same motif on the hdeD mRNA, RprA solely acts at the translational level, leaving the target RNA intact (Lalaouna et al. 2018).

Bacteria
Proteobacteria
HdeD of E. coli (P0AET5)
9.B.36.1.2









Uncharacterized protein of 226 aas and 6 TM

Bacteria
Actinobacteria
Uncharacterized protein of Streptomyces coelicolor
9.B.36.1.3









PF03729 (DUF308) family protein

Bacteria
Actinobacteria
DUF308 family member of Bifidobacterium longum
9.B.36.1.4









HdeD family acid-resistance protein of 183 aas and 6 TMSs.

Bacteria
Bacteroidetes
HdeD protein of Chitinophaga sp. MD30
9.B.36.1.5









Uncharacterized protein of 160 aas and 6 TMSs.

Archaea
Euryarchaeota
UP of Methanobrevibacter arboriphilus
9.B.36.1.6









Uncharacterized protein of 235 aas and 8 TMSs.

Archaea
Candidatus Lokiarchaeota
UP of Lokiarchaeum sp. GC14_75
9.B.36.1.7









Uncharacterized protein

Archaea
Euryarchaeota
Uncharacterized protein of Methanosarcina mazei
9.B.36.2.1









DR3 protein of 233 aas and 6 TMSs; involved in growth regulation and appoptosis (Zhang et al. 2009).

Eukaryota
Viridiplantae
DR3 of Synthrichia (Tortula) ruralis
9.B.36.2.2









RD3 homologue of 174 aas

Eukaryota
Viridiplantae
RD3 of Selaginella moellendorffii
9.B.36.3.1









Uncharacterized protein

Bacteria
Chlamydiae/Verrucomicrobia group
Uncharacterized protein of Parchlamydia acanthamoebae
9.B.36.3.2









HdeD family acid-resistance protein of 187 aas and 6 TMSs.

Bacteria
Proteobacteria
HdeD protein of Martelella mediterranea
9.B.36.4.1









Uncharacterized protein of 189 aas and 6 TMSs.

Archaea
Candidatus Bathyarchaeota
UP of Crenarchaeota group-6 archaeon AD8-1 (sediment metagenome)
9.B.36.4.2









UP of 194 aas and 6 TMSs.

Archaea
Candidatus Bathyarchaeota
UP of Crenarchaeota group-1 archaeon SG8-32-1
9.B.36.4.3









Uncharacterized protein of 223 aas and 6 TMSs.

Archaea
Candidatus Lokiarchaeota
UP of Candidatus Lokiarchaeota archaeon (marine sediment metagenome)
9.B.36.4.4









Uncharacterized protein of 207 aas and 6 TMSs

UP of Candidatus Heimdallarchaeota archaeon (marine sediment metagenome)
9.B.36.4.5









Uncharacterized protein of 166 aas and 6 TMSs

Archaea
Candidatus Bathyarchaeota
UP of Candidatus Bathyarchaeota archaeon (sediment metagenome)
9.B.36.4.6









Uncharacterized protein of 189 aas and 6 TMSs

Archaea
Euryarchaeota
UP of Candidatus Methanoplasma termitum
9.B.36.4.7









Uncharacterized protein of 182 aas and 6 TMSs.

Archaea
Euryarchaeota
UP of Methanomassiliicoccales archaeon (marine sediment metagenome)
9.B.36.5.1









Uncharacterized protein of 249 aas and 6 TMSs.

Bacteria
Actinobacteria
UP of Actinopolyspora mortivallis
9.B.36.5.2









Uncharacterized protein of 229 aas and 6 TMSs.

Bacteria
Actinobacteria
UP of Nonomuraea fuscirosea
9.B.36.5.3









Uncharacterized protein of 226 aas and 6 TMSs

Bacteria
Actinobacteria
UP of Nocardia brasiliensis
9.B.36.6.1









Uncharacterized DUF4386 protein of 249 aas and 6 TMSs in a 3 + 3 TMS arrangement

Bacteria
Proteobacteria
DUF4386 protein of Bauldia litoralis
9.B.36.6.2









Uncharacterized DUF4368 domain protein of 232 aas and 6 TMSs

Bacteria
Firmicutes
DUF4368 protein of Paenibacillus durus (Paenibacillus azotofixans)
9.B.36.6.3









Uncharacteerized DUF4368 domain protein of 240 aas and 6 TMSs.

Bacteria
Proteobacteria
UP of Permianibacter aggregans
9.B.36.6.4









Uncharacterized protein of 244 aas and 6 TMSs

UP of Chloroflexi bacterium UTCFX4 (bioreactor sludge metagenome)
9.B.36.7.1









Uncharacterized protein of 249 aas and 6 TMSs

Archaea
Candidatus Bathyarchaeota
UP of Candidatus Bathyarchaeota archaeon (soil metagenome)
9.B.36.7.2









Uncharacterized protein of 245 aas and 6 TMSs.

Bacteria
Actinobacteria
UP of Modestobacter multiseptatus
9.B.36.8.1









Uncharacterized protein of 222 aas and 6 TMSs

Bacteria
Proteobacteria
UP of Colwellia psychrerythraea
9.B.36.8.2









Uncharacterized DUF4368 domain protein of 230 aas and 6 TMSs.

Archaea
Euryarchaeota
DUF4368 protein of Halococcus saccharolyticus
9.B.36.8.3









Uncharacterized protein having  6 TMSs in a loose 3 TMS + tight 3 TMS arrangement with a DUF4386 domain.

Archaea
Euryarchaeota
UP of Candidatus Syntrophoarchaeum caldarius
9.B.36.8.4









Uncharacterized protein of 211 aas and 6 TMSs

Bacteria
UP of Terrabacteria group bacterium ANGP1 (soil metagenome)
9.B.36.8.5









Uncharacterized protein of 205 aas and 6 TMSs

UP of Candidatus Roizmanbacteria bacterium
9.B.36.8.6









DUF4386 domain-containing protein of 240 aas and 6 TMSs with the first 3 TMSs separated from each other more than the last 3 TMSs.

Bacteria
Actinobacteria
DUF4386 protein of Actinomadura fibrosa
9.B.36.9.1









Uncharacterized protein of 236 aas and 6 TMSs.

Archaea
Thaumarchaeota
UP of Thaumarchaeota archaeon (soil metagenome)
9.B.36.9.2









DUF4368 domain protein of 235 aas and 6 TMSs

Bacteria
Spirochaetes
DUF4368 protein of Leptospira sarikeiensis
9.B.36.9.3









DUF4386 domain-containing protein of 247 aas and 6 TMSs.

Bacteria
Cyanobacteria
DUF4368 domain protein of Trichormus variabilis
9.B.36.10.1









Uncharacterized protein of 227 aas and 6 TMSs

Bacteria
Candidatus Aminicenantes
UP of Candidatus Aminicenantes bacterium RBG_16_66_30 (subsurface metagenome)
9.B.36.10.2









Uncharacterized protein of 210 aas and 6 TMSs

Bacteria
Bacteroidetes
UP of Marinilabiliales bacterium (bioreactor metagenome)
9.B.36.11.1









Uncharacterized protein of 2009 aas and 6 TMSs.

Bacteria
Bacteroidetes
UP of Sphingobacteriales bacterium
9.B.36.11.2









Uncharacteerized protein of 212 aas and 6 TMSs

Bacteria
Proteobacteria
UP of Brevundimonas sp. Root1279
9.B.36.11.3









Uncharacterized protein of 217 aas and 6 TMSs

Bacteria
Gemmatimonadetes
UP of Gemmatimonas phototrophica
9.B.36.12.1









Uncharacterized protein of 227 aas and 6 TMSs.

Bacteria
Actinobacteria
UP of Geodermatophilus pulveris
9.B.36.12.2









Uncharacterized protein of 196 aas and 6 TMSs in a 3 + 3 TMS arrangement.

Bacteria
Actinobacteria
UP of Cryptosporangium sp.
9.B.36.12.3









Uncharacterized protein of 192 aas and 6 TMSs

UP of Paenibacillus hemerocallicola
9.B.36.12.4









Uncharacterized protein of 230 aas and 6 TMSs

Bacteria
Actinobacteria
UP of Rhodococcus maanshanensis
9.B.36.12.5









Uncharacterized protein of 219 aas and 6 TMSs.

Bacteria
Actinobacteria
UP of Arthrobacter globiformis
9.B.36.12.6









Uncharacterized protein of 237 aas and 6 or 7 TMSs.

Bacteria
Proteobacteria
UP of Pseudomonas fluvialis
9.B.36.12.7









Uncharacterized protein of 208 aas and 6 TMSs.

Bacteria
Actinobacteria
UP of Streptomyces aidingensis
9.B.36.12.8









Uncharacterized protein of 211 aas and 6 TMSs

Bacteria
Chloroflexi
UP of Ktedonobacter racemifer
9.B.36.12.9









Uncharacterized protein of 200 aas and 6 TMSs

Bacteria
Proteobacteria
UP of Ahrensia sp.
9.B.36.13.1









Uncharacterized protein of 477 aas and 12 TMSs in a 6 + 6 TMS, or 3 + 3 + 3 + 3 TMS arrangement.  Also shows some similarity with an MFS protein (TC# 2.A.1.2.41).

Bacteria
Actinobacteria
UP of Sinomonas sp.
9.B.36.13.2









Uncharacterized protein of 6 TMSs

Bacteria
Actinobacteria
UP of Kribbella jejuensis
9.B.36.13.3









Uncharacterized protein of 457 aas and 12 TMSs in a 3 + 3 + 3 + 3 TMS arrangement.

Bacteria
Actinobacteria
UP of Streptomyces sp.
9.B.36.13.4









Uncharacterized protein of 463 aas and 12 TMSs in a 3 + 3 + 3 + 3 TMS arrangement.

Bacteria
Actinobacteria
UP of Asanoa ferruginea
9.B.36.13.5









Uncharacterized protein of 240 aas and 6 TMSs.

Bacteria
Actinobacteria
UP of Actinopolymorpha singaporensis
9.B.36.14.1









Uncharacterized protein of 251 aas and 6 TMSs in a 1 + 2 + 3 TMS arrangement.

Bacteria
Proteobacteria
UP of Rhodopseudomonas palustris (Rhodopseudomonas rutila)
9.B.36.14.2









Uncharacterized protein of 242 aas and 6 TMSs.

Eukaryota
Fungi
UP of Aspergillus parasiticus
9.B.36.14.3









Uncharacterized protein of 242 aas and 6 TMSs in a 1 + 2 + 3 TMS arrangement.

Bacteria
Actinobacteria
UP of Mycolicibacterium rhodesiae
9.B.36.14.4









Uncharacterized protein of 225 aas and 6 TMSs in a 1 + 2 + 3 TMS arrangement.

Bacteria
Actinobacteria
UP of Mycobacterium conspicuum
9.B.36.14.5









Uncharacterized protein of 434 aas and 11 TMSs, where the last 5 TMSs (domain 2) are homologous to members of the COX family (e.g., 3.D.4.10.1; e-21) and the first 6 TMSs (domain 1) are homologous to 9.B.36.14.1; E-19 and other members of the HdeD family).  The C-terminal 5 TMSs occur in a 1 + 2 + 2 TMS arrangement.

Bacteria
Proteobacteria
UP of Novosphingobium lentum