| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
9.B.36.1.1 | The acid resistance 6 TMS HdeD protein of 190 aas. The yhiD and hdeD gene products participate in an acid resistance mechanism exhibited only at high cell densities (Mates et al. 2007). H-NS directly controls expression of the hedD gene (Krin et al. 2010). Both small RNAs, CyaR and RprA, interact with the 5'-UTR of hdeD mRNA, and binding to the RBS of hdeD, interfers with translational initiation. Lalaouna et al. 2018 identified an A/U-rich motif on hdeD, which is bound by the RNA chaperone Hfq. The results indicate that binding of this motif by Hfq is required for CyaR-induced degradation of hdeD mRNA, and two molecules of RprA must bind the 5'-UTR of hdeD to block translation initiation. While both CyaR and RprA sRNAs bind to the same motif on the hdeD mRNA, RprA solely acts at the translational level, leaving the target RNA intact (Lalaouna et al. 2018). Scavenger receptor CD36 mediates innate immune responses against infectious and non-infectious diseases (Banesh and Trivedi 2020). | Bacteria |
Pseudomonadota | HdeD of E. coli (P0AET5) |
|
9.B.36.1.2 | Uncharacterized protein of 226 aas and 6 TM | Bacteria |
Actinomycetota | Uncharacterized protein of Streptomyces coelicolor |
|
9.B.36.1.3 | PF03729 (DUF308) family protein | Bacteria |
Actinomycetota | DUF308 family member of Bifidobacterium longum |
|
9.B.36.1.4 | HdeD family acid-resistance protein of 183 aas and 6 TMSs. | Bacteria |
Bacteroidota | HdeD protein of Chitinophaga sp. MD30 |
|
9.B.36.1.5 | Uncharacterized protein of 160 aas and 6 TMSs. | Archaea |
Euryarchaeota | UP of Methanobrevibacter arboriphilus |
|
9.B.36.1.6 | Uncharacterized protein of 235 aas and 8 TMSs. | Archaea |
Candidatus Lokiarchaeota | UP of Lokiarchaeum sp. GC14_75 |
|
9.B.36.1.7 | Uncharacterized protein | Archaea |
Euryarchaeota | Uncharacterized protein of Methanosarcina mazei |
|
9.B.36.2.1 | DR3 protein of 233 aas and 6 TMSs; involved in growth regulation and appoptosis (Zhang et al. 2009). | Eukaryota |
Viridiplantae, Streptophyta | DR3 of Synthrichia (Tortula) ruralis |
|
9.B.36.2.2 | RD3 homologue of 174 aas | Eukaryota |
Viridiplantae, Streptophyta | RD3 of Selaginella moellendorffii |
|
9.B.36.3.1 | Uncharacterized protein | Bacteria |
Chlamydiota | Uncharacterized protein of Parchlamydia acanthamoebae |
|
9.B.36.3.2 | HdeD family acid-resistance protein of 187 aas and 6 TMSs. | Bacteria |
Pseudomonadota | HdeD protein of Martelella mediterranea |
|
9.B.36.4.1 | Uncharacterized protein of 189 aas and 6 TMSs. | Archaea |
Candidatus Bathyarchaeota | UP of Crenarchaeota group-6 archaeon AD8-1 (sediment metagenome) |
|
9.B.36.4.2 | UP of 194 aas and 6 TMSs. | Archaea |
Candidatus Bathyarchaeota | UP of Crenarchaeota group-1 archaeon SG8-32-1 |
|
9.B.36.4.3 | Uncharacterized protein of 223 aas and 6 TMSs. | Archaea |
Candidatus Lokiarchaeota | UP of Candidatus Lokiarchaeota archaeon (marine sediment metagenome) |
|
9.B.36.4.4 | Uncharacterized protein of 207 aas and 6 TMSs | Candidatus Heimdallarchaeota | UP of Candidatus Heimdallarchaeota archaeon (marine sediment metagenome) | |
|
9.B.36.4.5 | Uncharacterized protein of 166 aas and 6 TMSs | Archaea |
Candidatus Bathyarchaeota | UP of Candidatus Bathyarchaeota archaeon (sediment metagenome) |
|
9.B.36.4.6 | Uncharacterized protein of 189 aas and 6 TMSs | Archaea |
Candidatus Thermoplasmatota | UP of Candidatus Methanoplasma termitum |
|
9.B.36.4.7 | Uncharacterized protein of 182 aas and 6 TMSs. | Archaea |
Candidatus Thermoplasmatota | UP of Methanomassiliicoccales archaeon (marine sediment metagenome) |
|
9.B.36.5.1 | Uncharacterized protein of 249 aas and 6 TMSs. | Bacteria |
Actinomycetota | UP of Actinopolyspora mortivallis |
|
9.B.36.5.2 | Uncharacterized protein of 229 aas and 6 TMSs. | Bacteria |
Actinomycetota | UP of Nonomuraea fuscirosea |
|
9.B.36.5.3 | Uncharacterized protein of 226 aas and 6 TMSs | Bacteria |
Actinobacteria | UP of Nocardia brasiliensis |
|
9.B.36.6.1 | Uncharacterized DUF4386 protein of 249 aas and 6 TMSs in a 3 + 3 TMS arrangement | Bacteria |
Pseudomonadota | DUF4386 protein of Bauldia litoralis |
|
9.B.36.6.2 | Uncharacterized DUF4368 domain protein of 232 aas and 6 TMSs | Bacteria |
Bacillota | DUF4368 protein of Paenibacillus durus (Paenibacillus azotofixans) |
|
9.B.36.6.3 | Uncharacteerized DUF4368 domain protein of 240 aas and 6 TMSs. | Bacteria |
Pseudomonadota | UP of Permianibacter aggregans |
|
9.B.36.6.4 | Uncharacterized protein of 244 aas and 6 TMSs | Chloroflexota | UP of Chloroflexi bacterium UTCFX4 (bioreactor sludge metagenome) | |
|
9.B.36.7.1 | Uncharacterized protein of 249 aas and 6 TMSs | Archaea |
Candidatus Bathyarchaeota | UP of Candidatus Bathyarchaeota archaeon (soil metagenome) |
|
9.B.36.7.2 | Uncharacterized protein of 245 aas and 6 TMSs. | Bacteria |
Actinomycetota | UP of Modestobacter multiseptatus |
|
9.B.36.8.1 | Uncharacterized protein of 222 aas and 6 TMSs | Bacteria |
Pseudomonadota | UP of Colwellia psychrerythraea |
|
9.B.36.8.2 | Uncharacterized DUF4368 domain protein of 230 aas and 6 TMSs. | Archaea |
Euryarchaeota | DUF4368 protein of Halococcus saccharolyticus |
|
9.B.36.8.3 | Uncharacterized protein having 6 TMSs in a loose 3 TMS + tight 3 TMS arrangement with a DUF4386 domain. | Archaea |
Euryarchaeota | UP of Candidatus Syntrophoarchaeum caldarius |
|
9.B.36.8.4 | Uncharacterized protein of 211 aas and 6 TMSs | Bacteria |
UP of Terrabacteria group bacterium ANGP1 (soil metagenome) | |
|
9.B.36.8.5 | Uncharacterized protein of 205 aas and 6 TMSs | Candidatus Roizmanbacteria | UP of Candidatus Roizmanbacteria bacterium | |
|
9.B.36.8.6 | DUF4386 domain-containing protein of 240 aas and 6 TMSs with the first 3 TMSs separated from each other more than the last 3 TMSs. | Bacteria |
Actinomycetota | DUF4386 protein of Actinomadura fibrosa |
|
9.B.36.9.1 | Uncharacterized protein of 236 aas and 6 TMSs. | Archaea |
Nitrososphaerota | UP of Thaumarchaeota archaeon (soil metagenome) |
|
9.B.36.9.2 | DUF4368 domain protein of 235 aas and 6 TMSs | Bacteria |
Spirochaetota | DUF4368 protein of Leptospira sarikeiensis |
|
9.B.36.9.3 | DUF4386 domain-containing protein of 247 aas and 6 TMSs. | Bacteria |
Cyanobacteriota | DUF4368 domain protein of Trichormus variabilis |
|
9.B.36.10.1 | Uncharacterized protein of 227 aas and 6 TMSs | Bacteria |
Candidatus Aminicenantes | UP of Candidatus Aminicenantes bacterium RBG_16_66_30 (subsurface metagenome) |
|
9.B.36.10.2 | Uncharacterized protein of 210 aas and 6 TMSs | Bacteria |
Bacteroidota | UP of Marinilabiliales bacterium (bioreactor metagenome) |
|
9.B.36.11.1 | Uncharacterized protein of 2009 aas and 6 TMSs. | Bacteria |
Bacteroidota | UP of Sphingobacteriales bacterium |
|
9.B.36.11.2 | Uncharacteerized protein of 212 aas and 6 TMSs | Bacteria |
Pseudomonadota | UP of Brevundimonas sp. Root1279 |
|
9.B.36.11.3 | Uncharacterized protein of 217 aas and 6 TMSs | Bacteria |
Gemmatimonadota | UP of Gemmatimonas phototrophica |
|
9.B.36.12.1 | Uncharacterized protein of 227 aas and 6 TMSs. | Bacteria |
Actinomycetota | UP of Geodermatophilus pulveris |
|
9.B.36.12.2 | Uncharacterized protein of 196 aas and 6 TMSs in a 3 + 3 TMS arrangement. | Bacteria |
Actinomycetota | UP of Cryptosporangium sp. |
|
9.B.36.12.3 | Uncharacterized protein of 192 aas and 6 TMSs | Bacillota | UP of Paenibacillus hemerocallicola | |
|
9.B.36.12.4 | Uncharacterized protein of 230 aas and 6 TMSs | Bacteria |
Actinomycetota | UP of Rhodococcus maanshanensis |
|
9.B.36.12.5 | Uncharacterized protein of 219 aas and 6 TMSs. | Bacteria |
Actinomycetota | UP of Arthrobacter globiformis |
|
9.B.36.12.6 | Uncharacterized protein of 237 aas and 6 or 7 TMSs. | Bacteria |
Pseudomonadota | UP of Pseudomonas fluvialis |
|
9.B.36.12.7 | Uncharacterized protein of 208 aas and 6 TMSs. | Bacteria |
Actinomycetota | UP of Streptomyces aidingensis |
|
9.B.36.12.8 | Uncharacterized protein of 211 aas and 6 TMSs | Bacteria |
Chloroflexota | UP of Ktedonobacter racemifer |
|
9.B.36.12.9 | Uncharacterized protein of 200 aas and 6 TMSs | Bacteria |
Pseudomonadota | UP of Ahrensia sp. |
|
9.B.36.13.1 | Uncharacterized protein of 477 aas and 12 TMSs in a 6 + 6 TMS, or 3 + 3 + 3 + 3 TMS arrangement. Also shows some similarity with an MFS protein (TC# 2.A.1.2.41). | Bacteria |
Actinomycetota | UP of Sinomonas sp. |
|
9.B.36.13.2 | Uncharacterized protein of 6 TMSs | Bacteria |
Actinomycetota | UP of Kribbella jejuensis |
|
9.B.36.13.3 | Uncharacterized protein of 457 aas and 12 TMSs in a 3 + 3 + 3 + 3 TMS arrangement. | Bacteria |
Actinomycetota | UP of Streptomyces sp. |
|
9.B.36.13.4 | Uncharacterized protein of 463 aas and 12 TMSs in a 3 + 3 + 3 + 3 TMS arrangement. | Bacteria |
Actinomycetota | UP of Asanoa ferruginea |
|
9.B.36.13.5 | Uncharacterized protein of 240 aas and 6 TMSs. | Bacteria |
Actinomycetota | UP of Actinopolymorpha singaporensis |
|
9.B.36.14.1 | Uncharacterized protein of 251 aas and 6 TMSs in a 1 + 2 + 3 TMS arrangement. | Bacteria |
Pseudomonadota | UP of Rhodopseudomonas palustris (Rhodopseudomonas rutila) |
|
9.B.36.14.2 | Uncharacterized protein of 242 aas and 6 TMSs. | Eukaryota |
Fungi, Ascomycota | UP of Aspergillus parasiticus |
|
9.B.36.14.3 | Uncharacterized protein of 242 aas and 6 TMSs in a 1 + 2 + 3 TMS arrangement. | Bacteria |
Actinomycetota | UP of Mycolicibacterium rhodesiae |
|
9.B.36.14.4 | Uncharacterized protein of 225 aas and 6 TMSs in a 1 + 2 + 3 TMS arrangement. | Bacteria |
Actinomycetota | UP of Mycobacterium conspicuum |
|
9.B.36.14.5 | Uncharacterized protein of 434 aas and 11 TMSs, where the last 5 TMSs (domain 2) are homologous to members of the COX family (e.g., 3.D.4.10.1; e-21) and the first 6 TMSs (domain 1) are homologous to 9.B.36.14.1; E-19 and other members of the HdeD family). The C-terminal 5 TMSs occur in a 1 + 2 + 2 TMS arrangement. | Bacteria |
Pseudomonadota | UP of Novosphingobium lentum |