TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.387.1.1









Latent membrane protein-1, LMP1 of 386 aas with 6 N-terminal TMSs. Epstein-Barr Virus LMP1 modulates the CD63 interactome (Cheerathodi et al. 2021). CD63 proximal interacting proteins comprise the network of partners required for endocytic trafficking and extracellular vesicle cargo sorting, formation, and secretion (Cheerathodi et al. 2021).

Viruses
Peploviricota
LMP1 of Epstein-Barr virus (EBV)
9.B.387.1.2









LMP1 of 561 aas and 6 N-terminal TMSs

Viruses
Peploviricota
LMP1 of Macaca arctoides gammaherpesvirus 1
9.B.387.2.1









Latent membrane protein 2, LMP2, of 497 aas and 12 TMSs.  Isoform LMP2A  maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. It acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. It also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. It serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosine kinases. It possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs (Cen and Longnecker 2015).

Viruses
Peploviricota
LMP2 of Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
9.B.387.2.2









Callitrichine, C7. of 413 aas and 12 TMSs.

Viruses
Peploviricota
Callitrichine of gammaherpesvirus 3 (Marmoset lymphocryptovirus)