9.B.392.4.4
E3 ubiquitin-protein ligase (HUB2 of 844 aas) monoubiquitinates H2B to form H2BK143ub1 which
gives a specific tag for epigenetic transcriptional activation and is a
prerequisite for H3 Lys-4 methylation (H3K4me). It thereby plays a
central role in histone code and gene regulation (Cao et al. 2015, Du et al. 2016). Overexpression of this C3HC4-type E3-ubiquitin ligase contributes to salinity tolerance by modulating Na+ homeostasis in rice (Kim et al. 2023).
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| Accession Number: | Q336R3 |
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| Protein Name: | E3 ubiquitin-protein ligase BRE1-like 2 |
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| Length: | 844 |
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| Molecular Weight: | 96498.00 |
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| Species: | Oryza sativa subsp. japonica (Rice) [39947] |
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| Location1 / Topology2 / Orientation3: |
Nucleus1 |
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| Substrate |
protein |
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1: MDAAALQYEN QKLVQQLEAQ KSKMRALEGK FKELRDEQCS YDNTLICLNK MWNQLIDDLV
61: LLGVRAGGDL NGLQALDHEE MSEESLESCP SEEIFLFRLL NSRNFRNNDD SSLSKLVEEA
121: LALRYSTTVT LMKSLQEAFA VQQARSESLS LALNGQNSSE DVIVALENHN DYLKEVVDNL
181: RQAVSIINRK HEKYLDEIEA FKNNQSRELH EVKCLSGELE ESMAELEESR RKLAVLQLQT
241: GGGSLMNTSA PNGVNGSVST DKSSDKGMGW RDLKDAVEEA KTLAANRLFE LHETQEDNLI
301: LSKQLEDIQD QLKDENYIVT SKPYTILSDQ LHHLNAEIER YRGLVEVLQN EKDQLMQKEE
361: EMLAKAESVD AVQQSITTYK AKIEDLEHEI QKLMAEKNDL EIKAEEALQD SGKKDFKDEI
421: HVMAASLSKE MELLDNQMNR SKDAASEALA LREEADYLRT LLAKKIDEQK EISDRYNTQV
481: TEIKSLKALI ETLDQEKQEL QFIVDMLGKE CSESRAISEI EESENRARKQ AEYLRKCLEE
541: HNLELRVKAA NEAETACQQR LSIAEAELED LRAKVDASER DVMKLKESIR IKEAEVDGHI
601: SEIETIGQAY EDMQTQNQHL LQQVADRDDF NIKLVSDSVK MKQAYGSLLA EKNMLQKQLQ
661: HVNSSLESSK LKITSGEEQM KTYVAQAMKS SSENRHLAIS LERTMLEVSD AEKELKWLRS
721: ATGSAEKEYE INQKKIAELK MELERERNER IKLEEEYEEV KNEVSELTSE TEETTIQKLQ
781: DEIKECKAIL KCGVCFDRPK EVVITKCFHL FCSPCIQRNL EIRHRKCPGC GTPFGQSDVR
841: EVKI