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9.C.7 The Low-affinity, Calcium-blocked, Nonspecific Cation Channel (NSC1) Family

NSC1 of S. cerevisiaeis the primary low-affinity K+ uptake system, but the gene has not been cloned. K+ uptake is inhibited by (1) extracellular Ca2+, (2) low pH, (3) hydromycin B and (4) TEA+. The transporter probably transports K+, NH4+ and Li+ among other cations. It may function similarly to the mouse NSC1 (TC #1.A.14.1.1), but no S. cerevisiaegene product shows sequence similarity to this mouse channel protein.


References associated with 9.C.7 family:

Bihler, H., C.L. Slayman, and A. Bertl. (1998). NSC1: a novel high-current inward rectifier for cations in the plasma membrane of Saccharomyces cerevisiae. FEBS Lett. 432: 59-64. 9710251
Bihler, H., C.L. Slayman, and A. Bertl. (2002). Low-affinity potassium uptake by Saccharomyces cerevisiae is mediated by NSC1, a calcium-blocked non-specific cation channel. Biochim. Biophys. Acta. 1558: 109-118. 11779561