Major Facilitator (MFS) Superfamily
The Major Facilitator Superfamily (MFS) is the largest superfamily of secondary carriers known. It includes a few families of proteins that catalyze processes other than secondary transport. For example, evidence suggests that the Major Intrinsic Protein (MIP) family of aquaporins and glycerol channels is related to the MFS as are Rhomboid proteases and the glycosyl transferase (GT) superfamily. Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81. Reddy, V.S., M.A. Shlykov, R. Castillo, E.I. Sun, and M.H. Saier, Jr. (2012). The major facilitator superfamily (MFS) revisited. FEBS J. 279: 2022-2035. Wang et al., 2020, Expansion of the Major Facilitator Superfamily (MFS) to Include Novel Transporters as well as Transmembrane-Acting Enzymes, Biochmica Biophysica Acta, 1862, 18327, PMID 32205149.
2.A.1 - The Major Facilitator Superfamily (MFS)2.A.2 - The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family
2.A.12 - The ATP:ADP Antiporter (AAA) Family
2.A.17 - The Proton-dependent Oligopeptide Transporter (POT/PTR) Family
2.A.48 - The Reduced Folate Carrier (RFC) Family
2.A.57 - The Equilibrative Nucleoside Transporter (ENT) Family
2.A.60 - The Organo Anion Transporter (OAT) Family
2.A.71 - The Folate-Biopterin Transporter (FBT) Family
2.A.85 - The Aromatic Acid Exporter (ArAE) Family
2.A.100 - The Ferroportin (Fpn) Family
2.A.125 - The Eukaryotic Riboflavin Transporter (E-RFT) Family
4.H.1 - The Lysyl Phosphatidylglycerol Synthase/Flippase (MprF) Family
5.B.2 - The Eukaryotic Cytochrome b561 (Cytb561) Family
9.B.57 - The Conidiation and Conidial Germination Protein (CCGP) Family
9.B.111 - The 6 TMS Lysyl tRNA Synthetase (LysS) Family
9.B.143 - The 6 TMS DUF1275/Pf06912 (DUF1275) Family