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MACPF/TMPRSS/SelP-R Superfamily

The MACPF, TMPRSS and SelP-R families are usually characterized by two TMSs, N- and C-terminal, where the N-terminal TMS is the leader sequence for secretion, and the C-terminal TMS is the membrane anchor. As indicated, 3 families include members that are homologous to these proteins.

1.C.39 - The Membrane Attack Complex/Perforin (MACPF) Family
8.A.131 - The Transmembrane Protease Serine 3 (TMPRSS3) Family