TCDB is operated by the Saier Lab Bioinformatics Group

Basigin-Tapasin-TREM2/PIGR Superfamily

This family includes seven families including the Basigin Family (8.A.23), the Tapasin Family (8.A.196) and the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2/PIGR) Family (8.A.218). Homologs can also be found in the multi-component MHC II Receptor Complex (TC# 9.A.75) as well as the multi-component Invertebrate PMP22-Claudin (Claudin2) Family which includes 18 proteins in TCDB, 4 or which belong to the BTT Superfamily. Most of these proteins have variable sizes (from 215 aas to 909 aas), two TMSs, N- and C-terminal and from 1 to 5 internal repeats of about 110 aas.

8.A.17 - The Na+ Channel Auxiliary Subunit β1-β4 (SCA-β) Family
8.A.23 - The Basigin (Basigin) Family
8.A.43 - The NEAT-domain containing methaemoglobin heme sequestration (N-MHS) Family
8.A.77 - The Sheddase (Sheddase) Family
8.A.196 - The Tapasin (Tapasin) Family
8.A.218 - The Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Family
9.B.87 - The Selenoprotein P Receptor (SelP-Receptor) Family