Guided Entry of Tail-anchored Protein (GET) Superfamily

In Eukaryotes, tail-anchored proteins use a distinctive pathway for insertion. Animal systems are in TC# 3.A.19 while Fungal systems are in TC# 3.A.21. 3-D structural analyses suggest that the EMC family (TC# 3.A.27) is also a member of this superfamily as is the YidC family (TC# 2.A.9) (McDowell et al., 2020).