TCDB is operated by the Saier Lab Bioinformatics Group

Guided Entry of Tail-anchored Protein (GET) Superfamily

In Eukaryotes, tail-anchored proteins use a distinctive pathway for insertion. Animal systems are in TC# 3.A.19 while Fungal systems are in TC# 3.A.21. 3-D structural analyses suggest that the EMC family (TC# 3.A.27) is also a member of this superfamily as is the YidC family (TC# 2.A.9) (McDowell et al., 2020).

2.A.9 - The Membrane Protein Insertase (YidC/Alb3/Oxa1) Family
3.A.19 - The TMS Recognition/Insertion Complex (TRC) Family
3.A.21 - The C-terminal Tail-Anchored Membrane Protein Biogenesis/ Insertion Complex (TAMP-B) Family
3.A.27 - The Endoplasmic Reticulum Membrane Protein Insertion Complex (EMC) Family