1.A.122. The Avian Encephalomyelitis Virus protein 3A (AEV-3A) Family Avian encephalomyelitis virus (AEV) protein 3A is a membrane-interacting protein containing a stretch of 21 hydrophobic amino acyl residues. Residues 45-51, the most C-terminal hydrophobic domain, are essential for membrane integration in the ER (Liu et al. 2004) and large pore-formation (able to transport proteins). This motif within the transmembrane domain is essential for the stable interaction of the protein 3A with the ER membrane.
References:
Liu, J., T. Wei, and J. Kwang. (2004). Membrane-association properties of avian encephalomyelitis virus protein 3A. Virology 321: 297-306.
Examples:
TC#	Name	Organismal Type	Example
1.A.122.1.1	*Putative protein 3A of Tremovirus A of 65 aas and 1 central TMS. It forms a pore in the ER membrane (Liu et al.* 2004).**		Protein 3A of Tremovirus A

1.A.122.1.2	Polyprotein of 2134 aas from which protein 3A is derived.		Polyprotein 2134 of Avian encephalomyelitis virus