1.A.145.  The gp120 Viroporin (gp120-VP) Family

This family has been examined, first, showing that its characterized member is a  small transmembrane protein of 100 aas and 1 centrally located TMS (residues 45 - 69). Second, it has been shown to have ion channel activity (Basu et al. 2023). Third, its 3-D transmembrane structure has been predicted using alpha-fold.


TC#NameOrganismal TypeExample

MPXVgp120 viroporin protein of 100 aas and 1 C-terminal TMS.


MPXVgp120 viroporin of Monkeypox virus


Putative viroporin of 65 aas and 2 TMSs, SWPV1-219. 

SWPV1-219 of Shearwater pox virus


 IMV membrane protein, putative viroporin, of 74 aas and 1 C-terminal TMS. 

Viroporin of Nile crocodilepox virus