1.D.106.  The Synthetic Self-assembly Y-shaped Aromatic Pore-precursor (SSYAP) Family 

The SSYAP family resulted from a complex synthesis pathway resulting in the preparation of a Y-shaped hydrophobic aromatic string of residues and chemical moieties that insert into membranes to form pores, therreby killing cancer cells (Du et al. 2018). Self-assembly-directed membrane insertion of the synthetic analogues was observed. An expanded pi-conjugation-based molecular precursor resulted that had extremely high rigidity and a long hydrophobic length that was comparable to the hydrophobic width of a plasma membrane. The originally soluble precursors were transformed into hydrophobic monomers for self-assembly, inserting  exclusively into the fluid phase of membranes. Membrane insertion of these rigid synthetic analogues destroyed the selective permeability of the membrane (Du et al. 2018).


 

References:

Du, E., X. Hu, G. Li, S. Zhang, D. Mang, S. Roy, T. Sasaki, and Y. Zhang. (2018). Self-Assembly-Directed Cancer Cell Membrane Insertion of Synthetic Analogues for Permeability Alteration. Langmuir. [Epub: Ahead of Print]