1.D.170. The Kaempferol Derivative Pore-forming (KDP) Family

Antimicrobial peptides (AMPs) act on the membrane bilayer of pathogens, causing leakage of the membrane and cell death. Amphiphilic kaempferol derivatives possessing basic functional groups show excellent antibacterial activities. Free energy changes for permeation into the bilayer for kaempferol (1), a tertiary amine derivative (2), and an arginine derivative (3) were calculated to be -1.5, -48.2, and -100.3 kJ/mol, respectively, which correlate with their antibacterial activity. Furthermore, compound 3 forms a stable toroidal pore in the membrane when multiple molecules are oriented in a transmembrane configuration (Daison et al. 2021).



Daison, F.A., N. Kumar, S. Balakrishnan, K. Venugopal, S. Elango, and P. Sokkar. (2021). Molecular Dynamics Studies on the Bacterial Membrane Pore Formation by Small Molecule Antimicrobial Agents. J Chem Inf Model. [Epub: Ahead of Print]