1.D.184.  Ion-selective Crown-ether Crystal Pore (IS-CE-P) Family

Artificial solid-state ionic devices enable separation technologies. Ye et al. 2021 reported an artificial sodium-selective ionic device, built on synthesized porous crown-ether crystals which consist of densely packed 0.26-nm-wide pores. The Na+ selectivity of the artificial sodium-selective ionic device reached 15 against K +, which is comparable to the biological counterpart, 523 against Ca2 + , which is nearly two orders of magnitude higher than the biological one, and 1128 against Mg2 + . The selectivity may arise from the size effect and molecular recognition effect.

Crown ethers (CEs) are widely studied in the area of artificial ion channels owing to their intrinsic host-guest interaction with different kinds of organic and inorganic ions. Other advantages such as lower price, chemical stability, and easier modification also make CE a research hotspot in the field of synthetic transmembrane nanopores. And numerous CEs-based membrane-active synthetic ion channels were designed and fabricated in the past. Recent progress of CEs-based synthetic ion transporters has been comprehensively summarized in a review, including their design principles, functional mechanisms, controllable properties, and biomedical applications (He et al. 2023).



This family belongs to the Crown Ether Artificial Ion Transporter Superfamily.

 

References:

He, L., T. Zhang, C. Zhu, T. Yan, and J. Liu. (2023). Crown Ether-Based Ion Transporters in Bilayer Membranes. Chemistry. [Epub: Ahead of Print]

Ye, T., G. Hou, W. Li, C. Wang, K. Yi, N. Liu, J. Liu, S. Huang, and J. Gao. (2021). Artificial sodium-selective ionic device based on crown-ether crystals with subnanometer pores. Nat Commun 12: 5231.