1.D.184.  Ion-selective Crown-ether Crystal Pore (IS-CE-P) Family

Artificial solid-state ionic devices enable separation technologies. Ye et al. 2021 reported an artificial sodium-selective ionic device, built on synthesized porous crown-ether crystals which consist of densely packed 0.26-nm-wide pores. The Na+ selectivity of the artificial sodium-selective ionic device reached 15 against K +, which is comparable to the biological counterpart, 523 against Ca2 + , which is nearly two orders of magnitude higher than the biological one, and 1128 against Mg2 + . The selectivity may arise from the size effect and molecular recognition effect.

Crown ethers (CEs) are widely studied in the area of artificial ion channels owing to their intrinsic host-guest interaction with different kinds of organic and inorganic ions. Other advantages such as lower price, chemical stability, and easier modification also make CE a research hotspot in the field of synthetic transmembrane nanopores. And numerous CEs-based membrane-active synthetic ion channels were designed and fabricated in the past. Recent progress of CEs-based synthetic ion transporters has been comprehensively summarized in a review, including their design principles, functional mechanisms, controllable properties, and biomedical applications (He et al. 2023).

This family belongs to the Crown Ether Artificial Ion Transporter Superfamily.



He, L., T. Zhang, C. Zhu, T. Yan, and J. Liu. (2023). Crown Ether-Based Ion Transporters in Bilayer Membranes. Chemistry. [Epub: Ahead of Print]

Ye, T., G. Hou, W. Li, C. Wang, K. Yi, N. Liu, J. Liu, S. Huang, and J. Gao. (2021). Artificial sodium-selective ionic device based on crown-ether crystals with subnanometer pores. Nat Commun 12: 5231.