1.D.97. The Diketal Mannitol Anion Channel (DKM-AC) Family DKM forms hydrogen-bonded, cyclic, rosette-motif, self-assembled anion channels consisting of 3 - 4 DKM units forming transmembrane channels with halide selectivity and a preference order: Cl^- > Br^- > I^- (Saha et al. 2014). The anions probably 'hop' from one unit to another through a channel that appears to have an inner diameter of 3.06 Å, a value that is close to the diameter of a dehydrated Cl^-. Thus, the transmembrane channel consists of a stack of cyclic rosettes stabilized by a balance between hydroophilic H-bonding interactions and hydrophobic interactions between the cyclohexyl side chains and the lipid bilayer (Gale et al. 2017).
References:
Gale, P.A., J.T. Davis, and R. Quesada. (2017). Anion transport and supramolecular medicinal chemistry. Chem Soc Rev 46: 2497-2519.
Saha, T., S. Dasari, D. Tewari, A. Prathap, K.M. Sureshan, A.K. Bera, A. Mukherjee, and P. Talukdar. (2014). Hopping-mediated anion transport through a mannitol-based rosette ion channel. J. Am. Chem. Soc. 136: 14128-14135.