1.D.97. The Diketal Mannitol Anion Channel (DKM-AC) Family

DKM forms hydrogen-bonded, cyclic, rosette-motif, self-assembled anion channels consisting of 3 - 4 DKM units forming transmembrane channels with halide selectivity and a preference order: Cl- > Br- > I- (Saha et al. 2014). The anions probably 'hop' from one unit to another through a channel that appears to have an inner diameter of 3.06 Å, a value that is close to the diameter of a dehydrated Cl-. Thus, the transmembrane channel consists of a stack of cyclic rosettes stabilized by a balance between hydroophilic H-bonding interactions and hydrophobic interactions between the cyclohexyl side chains and the lipid bilayer (Gale et al. 2017). 




Gale, P.A., J.T. Davis, and R. Quesada. (2017). Anion transport and supramolecular medicinal chemistry. Chem Soc Rev 46: 2497-2519.

Saha, T., S. Dasari, D. Tewari, A. Prathap, K.M. Sureshan, A.K. Bera, A. Mukherjee, and P. Talukdar. (2014). Hopping-mediated anion transport through a mannitol-based rosette ion channel. J. Am. Chem. Soc. 136: 14128-14135.