2.A.128. The Multidrug Resistance Exporter VanZ (VanZ) Family
The antibiotic resistance gene vanZ has been identified, and expression of vanZ conferred resistance to teicoplanin and dalbavancin in Streptococcus agalactiae (Lai et al. 2017).
The 4 TMS VanZ MDR export system confers resistance to teicoplanin and dalbavancin in Streptococcus agalactiae (Lai et al. 2017).
VanZ of Streptococcus agalactiae
VanZ homologue of 224 aas and 6 TMSs
VanZ homologue of Flavisolibacter ginsengisoli
VanZ family proteinof 122 aas and 4 TM
VanZ of Roseivirga seohaensis
Teicoplanin resistance protein VanZ of 120 aas and 4 TMSs.
VanZ of Campylobacter concisus
VanZ family proteinof 204 aas and 5 TMSs
VanZ of Parapedobacter indicus
VanZ family proteinof 125 aas and 4 TM
VanZ of Nostoc carneum
Uncharacterized protein of 247 aas and 8 TMSs, where the first 4 TMSs are homologous to VanZ proteins
UP of Phycisphaerae bacterium
VanZ family proteinof 119 aas and 4 TMSs.
VanZ of Pelodictyon phaeoclathratiforme
VanZ like family proteinof 118 aas and 4 TM
VanZ of Flavobacterium terrigena
VanZ like family proteinof 270 aas and 4 central TM
VanZ of Colletotrichum nymphaeae
VanZ family protein of 202 aas and 5 TMSs in a 1 + 2 + 2 arrangement.
VanZ of Enterococcus asini
VanZ homologue of 210 aas and 5 TMSs.
VanZ of Bacillus cereus
Teicoplanin resistance protein, VanZ1 of 169 aas and 5 (or 6) putative TMSs in a 1 + 4 arrangement (or in a 6 TMS arrangement). Its synthesis is induced by the antiicrobial peptide, LL-37 (1.C.33.1.10), but not by many other antimicrobials tested (Woods et al. 2018).
VanZ1 of Peptoclostridium difficile (Clostridium difficile)
VanZ homologue of 181 aas and 5 TMSs
VanZ of Listeria grandensis
VanZ homologue of 143 aas and 4 TMSs
VanZ of Ruminococcus flavefaciens
VanZ/RDD domain protein of 386 aas and 9 TMSs
VanZ/RDD protein of Erysipelothrix rhusiopathiae
VanZ homologue of 243 aas and 5 TMSs.
VanZ of Amycolatopsis orientalis
VanZ homologue of 162 aas and 4 TMSs.
VanZ of Streptomyces afghaniensis
VanZ homologue of 202 aas and 5 TMSs
VanZ of Cellulosimicrobium cellulans
VanZ homologue of 436 aas and 7 TM
VanZ of Mycoplasma sp. CAG:472
VanZ family protein of 163 aas and 4 TM
VanZ of Blastopirellula cremea
Teicoplanin resistance protein, VanZ of 164 aas and 3 or 4 TMSs.
VanZ of Clostridium acetobutylicum
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase of 743 aas and an N-terminal hydrophobic domain with 4 TMSs that are homologous to VanZ family members.
N-terminal VanZ domain protein of Eubacterium sp. An3
VanZ family proteinof 135 aas and 4 TMSs.
VanZ of Cohnella thermotolerans
Uncharacterized proteinof 203 aas and 6 TMSs.
UP of Methanolobus vulcani
VanZ family protein of 129 aas andd 4 TMSs
VanZ of Asaccharobacter celatus
VanZ like family proteinof144 aas and 4 TMSs.
VanZ of Lokiarchaeum sp.
VanZ family protein of 158 aas and 4 TMSs.
VanZ of Verrucomicrobia bacterium (marine metagenome)