2.A.128. The Multidrug Resistance Exporter VanZ (VanZ) Family The antibiotic resistance gene vanZ has been identified, and expression of vanZ conferred resistance to teicoplanin and dalbavancin in Streptococcus agalactiae (Lai et al. 2017). The bacterial proton motive force (PMF) represents a target, providing a comprehensive approach to controlling antimicrobial resistance (Yang et al. 2023).
References:
Lai, L., J. Dai, H. Tang, S. Zhang, C. Wu, W. Qiu, C. Lu, H. Yao, H. Fan, and Z. Wu. (2017). Streptococcus suis serotype 9 strain GZ0565 contains a type VII secretion system putative substrate EsxA that contributes to bacterial virulence and a vanZ-like gene that confers resistance to teicoplanin and dalbavancin in Streptococcus agalactiae. Vet Microbiol 205: 26-33.
Woods, E.C., D. Wetzel, M. Mukerjee, and S.M. McBride. (2018). Examination of the Clostridioides (Clostridium) difficile VanZ ortholog, CD1240. Anaerobe. [Epub: Ahead of Print]
Yang, B., Z. Tong, J. Shi, Z. Wang, and Y. Liu. (2023). Bacterial proton motive force as an unprecedented target to control antimicrobial resistance. Med Res Rev. [Epub: Ahead of Print]
Examples:
TC#	Name	Organismal Type	Example
2.A.128.1.1	*The 4 TMS VanZ MDR export system confers resistance to teicoplanin and dalbavancin in Streptococcus agalactiae* (Lai et al. 2017).**		VanZ of Streptococcus agalactiae

2.A.128.1.10	VanZ homologue of 224 aas and 6 TMSs		VanZ homologue of Flavisolibacter ginsengisoli

2.A.128.1.11	VanZ family proteinof 122 aas and 4 TM		VanZ of Roseivirga seohaensis

2.A.128.1.12	Teicoplanin resistance protein VanZ of 120 aas and 4 TMSs.		VanZ of Campylobacter concisus

2.A.128.1.13	VanZ family proteinof 204 aas and 5 TMSs		VanZ of Parapedobacter indicus

2.A.128.1.14	VanZ family proteinof 125 aas and 4 TM		VanZ of Nostoc carneum

2.A.128.1.15	Uncharacterized protein of 247 aas and 8 TMSs, where the first 4 TMSs are homologous to VanZ proteins		UP of Phycisphaerae bacterium

2.A.128.1.16	VanZ family proteinof 119 aas and 4 TMSs.		VanZ of Pelodictyon phaeoclathratiforme

2.A.128.1.17	VanZ like family proteinof 118 aas and 4 TM		VanZ of Flavobacterium terrigena

2.A.128.1.18	VanZ like family proteinof 270 aas and 4 central TM		VanZ of Colletotrichum nymphaeae

2.A.128.1.19	VanZ family protein of 202 aas and 5 TMSs in a 1 + 2 + 2 arrangement.		VanZ of Enterococcus asini

2.A.128.1.2	VanZ homologue of 210 aas and 5 TMSs.		VanZ of Bacillus cereus

2.A.128.1.20	Teicoplanin resistance protein, VanZ1 of 169 aas and 5 (or 6) putative TMSs in a 1 + 4 arrangement (or in a 6 TMS arrangement). Its synthesis is induced by the antiicrobial peptide, LL-37 (1.C.33.1.10), but not by many other antimicrobials tested (Woods et al. 2018).		VanZ1 of Peptoclostridium difficile (Clostridium difficile)

2.A.128.1.3	VanZ homologue of 181 aas and 5 TMSs		VanZ of Listeria grandensis

2.A.128.1.4	VanZ homologue of 143 aas and 4 TMSs		VanZ of Ruminococcus flavefaciens

2.A.128.1.5	VanZ/RDD domain protein of 386 aas and 9 TMSs		VanZ/RDD protein of Erysipelothrix rhusiopathiae

2.A.128.1.6	VanZ homologue of 243 aas and 5 TMSs.		VanZ of Amycolatopsis orientalis

2.A.128.1.7	VanZ homologue of 162 aas and 4 TMSs.		VanZ of Streptomyces afghaniensis

2.A.128.1.8	VanZ homologue of 202 aas and 5 TMSs		VanZ of Cellulosimicrobium cellulans

2.A.128.1.9	VanZ homologue of 436 aas and 7 TM		*VanZ of Mycoplasma* sp. CAG:472**

Examples:
TC#	Name	Organismal Type	Example
2.A.128.2.1	VanZ family protein of 163 aas and 4 TM		VanZ of Blastopirellula cremea

2.A.128.2.2	Teicoplanin resistance protein, VanZ of 164 aas and 3 or 4 TMSs.		VanZ of Clostridium acetobutylicum

2.A.128.2.3	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase of 743 aas and an N-terminal hydrophobic domain with 4 TMSs that are homologous to VanZ family members.		N-terminal VanZ domain protein of Eubacterium sp. An3

2.A.128.2.4	VanZ family proteinof 135 aas and 4 TMSs.		VanZ of Cohnella thermotolerans

2.A.128.2.5	Uncharacterized proteinof 203 aas and 6 TMSs.		UP of Methanolobus vulcani

2.A.128.2.6	VanZ family protein of 129 aas andd 4 TMSs		VanZ of Asaccharobacter celatus

2.A.128.2.7	VanZ like family proteinof144 aas and 4 TMSs.		*VanZ of Lokiarchaeum* sp.**

2.A.128.2.8	VanZ family protein of 158 aas and 4 TMSs.		*VanZ of Verrucomicrobia bacterium* (marine metagenome)**