2.B.148. The Aryl-extended Calix[4]Pyrrole (ACP) Family

The binding of charged and neutral polar guests with these macrocyclic receptors in organic solvents and in water. have been described. Escobar et al. 2023 described the applications of calix[4]pyrrole derivatives in the sensing of creatinine, the facilitated transmembrane transport of anions and amino acids, and the monofunctionalization of bis-isonitriles. They explained the use of calix[4]pyrrole receptors as model systems for the quantification of anion-π interactions and the hydrophobic effect. They also discuss the self-assembly of dimeric capsules and unimolecular metallo-cages based on calix[4]pyrrole scaffolds. They comment on their binding properties, as well as on those of bis-calix[4]pyrroles having a fully covalent structure.  In molecular recognition, aryl-extended calix[4]pyrroles and their derivatives are considered valuable receptors owing to their ability to interact with a wide variety of electron-rich, neutral, and charged guests. Calix[4]pyrrole scaffolds have also been applied in the development of molecular sensors, ionophores, transmembrane carriers, supramolecular protecting groups and molecular containers, modulating chemical reactivity, among others. 

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