8.A.119. The Potassium Channel Regulatory Protein Sup-10 (Sup-10) Family The proteins within this family seem to have multiple functions. One of these is to coordinate muscle contraction as a regulatory subunit of nonessential potassium channel complexes such as the Sup-9 K+ channel of C. elegans (TC# 1.A.1.9.7). It also forms a complex with MFS protein Unc-93 which may also play a regulatory role in this complex (de la Cruz et al. 2003).
This family belongs to the Vesicle-associated Membrane Protein (VAMP) Superfamily.
References:
de la Cruz, I.P., J.Z. Levin, C. Cummins, P. Anderson, and H.R. Horvitz. (2003). sup-9, sup-10, and unc-93 may encode components of a two-pore K⁺ channel that coordinates muscle contraction in Caenorhabditis elegans. J. Neurosci. 23: 9133-9145.
Examples:
TC#	Name	Organismal Type	Example
8.A.119.1.1	*Sup-10 of 332 aas and 2 TMSs, one near the N-terminus, and one at the C-terminus. It plays a role in K⁺ channel (Sup-9) regulation in C. elegans* (see 1.A.1.9.7) (de la Cruz et al. 2003).**		Sup-10 of Caenorhabditis elegans

8.A.119.1.2	Major sperm protein of 489 aas and 2 TMSs, one near the N-terminus, and one at the C-terminus. It is a central component in molecular interactions underlying sperm motility. It forms an extensive filament system that extends from sperm villipoda along the leading edge of the pseudopod.		*Major sperm protein of Trichuris suis* (pig whipworm)**

8.A.119.1.3	Uncharacterized protein of 214 aas and 2 TMSs, one C-terminal and one N-terminal.		*UP of Necator americanus* (Human hookworm)**

8.A.119.1.4	Uncharacterized protein of 233 aas and 2 TMSs.		UP of Anisakis simplex (herring worm)

8.A.119.1.5	Uncharacterized protein of 271 aas and 1 TMSs.		*UP of Toxocara canis* (dog roundworm)**

8.A.119.1.6	MSP (Major sperm protein) domain-containing protein (pfam00635) of 142 aas and 1 TMS.		MSP protein of Oesophagostomum dentatum