8.A.119.  The Potassium Channel Regulatory Protein Sup-10 (Sup-10) Family 

The proteins within this family seem to have multiple functions.  One of these is to coordinate muscle contraction as a regulatory subunit of nonessential potassium channel complexes such as the Sup-9 K+ channel of C. elegans (TC# 1.A.1.9.7).  It also forms a complex with MFS protein Unc-93 which may also play a regulatory role in this complex (de la Cruz et al. 2003).

This family belongs to the Vesicle-associated Membrane Protein (VAMP) Superfamily.



de la Cruz, I.P., J.Z. Levin, C. Cummins, P. Anderson, and H.R. Horvitz. (2003). sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans. J. Neurosci. 23: 9133-9145.


TC#NameOrganismal TypeExample

Sup-10 of 332 aas and 2 TMSs, one near the N-terminus, and one at the C-terminus. It plays a role in K+ channel (Sup-9) regulation in C. elegans (see 1.A.1.9.7) (de la Cruz et al. 2003).

Sup-10 of Caenorhabditis elegans


Major sperm protein of 489 aas and 2 TMSs, one near the N-terminus, and one at the C-terminus.  It is a central component in molecular interactions underlying sperm motility. It forms an extensive filament system that extends from sperm villipoda along the leading edge of the pseudopod.

Major sperm protein of Trichuris suis (pig whipworm)


Uncharacterized protein of 214 aas and 2 TMSs, one C-terminal and one N-terminal.

UP of Necator americanus (Human hookworm)


Uncharacterized protein of 233 aas and 2 TMSs.

UP of Anisakis simplex (herring worm)


Uncharacterized protein of 271 aas and 1 TMSs.

UP of Toxocara canis (dog roundworm)


MSP (Major sperm protein) domain-containing protein (pfam00635) of 142 aas and 1 TMS.

MSP protein of Oesophagostomum dentatum