8.A.216.  The Golgi SNAP Receptor Complex, Member 1 (GOSR1) Family 

The proteins of this family are involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. GS28 belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors. It may play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). It also participates in docking and fusion stages of ER to cis-Golgi transport. It plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.


 

References:

Lee, H.O., Y.J. Byun, K.O. Cho, S.Y. Kim, S.B. Lee, H.S. Kim, O.J. Kwon, and S.W. Jeong. (2011). GS28 Protects Neuron.al Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition. Korean J. Physiol. Pharmacol 15: 149-156.

Examples:

TC#NameOrganismal TypeExample
8.A.216.1.1

The Golgi SNAP receptor complex, member 1, GS28 or GOSR1, of 250 aas with one C-terminal TMS.  It is involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. It may play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). It participates in docking and fusion stage of ER to cis-Golgi transport and plays important physiological roles in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. GS28 protects against neuronal cell death mediated in response to hydrogen peroxide (Lee et al. 2011).

GS28 of Homo sapiens

 
8.A.216.1.2

Uncharacterized protein, BB560_004092, of 209 aas and 1 C-terminal TMS.

UP of Smittium megazygosporum

 
8.A.216.1.3

v-SNARE protein of 220 aas and 1 C-terminal TMS 

 

v-SNARE protein of Blastocystis sp.

 
8.A.216.1.4

Golgi SNARE protein-like protein of 277 aas and 1 C-terminal TMS.

Snare protein of Leishmania braziliensis

 
8.A.216.1.5

Protein transport protein bos1 of 240 aas and 1 C-terminal TM

Bos1 of Chytriomyces hyalinus

 
8.A.216.1.6

Uncharacterized protein of 415 aas and possibly two TMSs at residues 140 - 170 and 360 - 390.  It may be duplicated, but the C-terminal domain show the greatest sequence similarities with other members of this family.

UP of Smallanthus sonchifolius