The TMEM79 protein in humans, Matt, is of 394 aas with a 200 aa long N-terminal domain followed by a C-terminal integral membrane domain with 5 putative TMSs. It regulates TRPV3 (TC# 1.A.4.2.9) (Lei et al. 2023) and contributes to epidermal integrity and the skin barrier function. It also plays roles in the lamellar granule (LG) secretory system and in stratum corneum (SC) epithelial cell formation. It is involvement of skin TRPV3 temperature detection regulation in mice (Lei et al. 2023).

TMEM79 of Homo sapiens

Uncharacterized protein of 536 aas and 7 C-terminal TMSs.  The N-terminal 290 aas and hydrophilic while the remainder of the protein is hydrophobic with 7 putative TMSs.

UP of Naegleria gruberi

MAPEG family protein of 171 aas and 5 TMSs in a 2 + 3 TMS arrangement.

MAPEG protein of Bradyrhizobium sp.

Uncharacterized protein of 385 aas and 7 - 9 TMSs in a 2 + 2 + 3 TMS arrangement with possibly 2 more TMSs in a 3 + 2 + 4 TMS arrangement.

UP of Mytilus edulis

TMEM79 of 187 aas and 5 TMSs in a 2 + 3 TMS arrangement.

TMEM79 of Holothuria leucospilota

Epithelial cell maturation (EMC) protein of 448 aas and 5 (or 7) TMSs in a 3 + 2 (+- 2) TMS arrangement.

EMC protein of Tyrophagus putrescentiae

C-myc promoter-binding protein of 206 aas and 5 TMSs in a 2 + 3 TMS arrangement.

C-myc BP of Plakobranchus ocellatus

Eomesodermin-like protein of 932 aas with 5 C-terminal TMSs in a 2 + 3 TMS arrangement.

ELP of Biomphalaria glabrata