8.A.233.  The Scotin (Shisa-5) Family 

Scotin (Shisa-5) can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. Scotin is a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane (Bourdon et al. 2002).  proposed that SCOTIN impedes the ER-to-Golgi transport through its ability to form biomolecular condensates at the ER membrane (Kim et al. 2023).


 

References:

Bourdon, J.C., J. Renzing, P.L. Robertson, K.N. Fernandes, and D.P. Lane. (2002). Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. J. Cell Biol. 158: 235-246.

Kim, N., T.H. Kim, C. Kim, J.E. Lee, M.G. Kang, S. Shin, M. Jung, J.S. Kim, J.Y. Mun, H.W. Rhee, S.Y. Park, Y. Shin, and J.Y. Yoo. (2023). Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport. Dev Cell 58: 1950-1966.e8.

Examples:

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