8.A.42 The small hydrophilic YodL domain/protein (YodL) Family

The small cytoplasmic YodL protein of 104 aas in Bacillus subtilis can be found as individual proteins or as internal domains in Ni2+/Co2+ transport proteins of the NicO family (TC# 2.A.113).  The yodL gene in B. subtilis is adjacent to yodM and probably in the same operon.  YodM is probably a phsophatidic acid phosphatase.  The YodL domain is sandwiched in between the two 3 TMS NicO domains in proteins with TC#s 2.A.113.1.1 - 2.A.113.1.3 but is absent in TC#s 2.A.52.2.4-6 which however are very sequence similar to TC#s 2.A.52.2.1-3 in the NicO domains. These 3 TMS NicO domains may correspond to TMSs 2-4 and 6-8 in the 8 TMS NiCoT homologues (TC#s 1.A.52.1.1 - 4), but these two groups of proteins are very sequence divergent to each other.


Examples:

TC#NameOrganismal TypeExample
8.A.42.1.1

Small cytoplasmic YodL protein of 104 aas.  The yodL gene is adjacent to yodM and probably in the same operon.  YodM is a phsophatidic acid phosphatase.  The YodL domain is sandwiched in between the two 3 TMS NicO domains in proteins with TC#s 2.A.113.1.1 - 2.A.113.1.3 but is absent in TC#s 2.A.113.1.4-6 which however are very sequence similar to TC#s 2.A.111.1-3 in the NicO domains. These NicO domains may correspond to TMSs 2-4 and 6-8 in the 8 TMS homologues of NiCoT family members (TC#s 1.A.52.1.1 - 4), but these two families of porters are very divergent in sequence. 

Firmicutes

YodL of Bacillus subtilis

 
8.A.42.1.2

YodL homologue, YokX of 105 aas

Firmicutes

YokX of Bacillus pumilus

 
8.A.42.1.3

putative DNA primase of 109 aas

Firmicutes

Putative primase of Ruminococcus albus

 
8.A.42.1.4

YodL homologue of 107 aas

Firmicutes

YodL homologue of Bacillus megaterium

 
8.A.42.1.5

YodL homologue of 116 aas

Firmicutes

YodL homologue of Anoxybacillus flavithermus

 
8.A.42.1.6

Uncharaterized protein of 356 aas with an N-terminal YodL domain

Firmicutes

UP of Butyrivibrio crossotus