8.B.36.  The Contulakin Lt (Contulakin Lt) Family 

The conotoxins of this family inhibit GPCRs.



This family belongs to the Conotoxin Superfamily.

Examples:

TC#NameOrganismal TypeExample
8.B.36.1.1

Contulakin Lt1 of 85 aas with 1 N-terminal TMS.  It acts as an agonist of neurotensin receptors and binds to the human neurotensin type 1 receptor (NTSR1)

Contulakin Lt1 of Conus litteratus (Lettered cone)

 
8.B.36.1.2

Alpha-conotoxin OIVA or PrXA of 85 aas and 1 N-terminal TMS.

α-Conotoxin of Conus parius

 
8.B.36.1.3

Contulakin-G of 76 aas and 1 N-terminal TMS.  Acts as an agonist of neurotensin receptors. It binds to human neurotensin type 1 receptor (NTSR1)

Contulakin-G of Conus geographus (Geography cone) (Nubecula geographus)