8.B.36. The Contulakin Lt (Contulakin Lt) Family
The conotoxins of this family inhibit GPCRs.
Contulakin Lt1 of 85 aas with 1 N-terminal TMS. It acts as an agonist of neurotensin receptors and binds to the human neurotensin type 1 receptor (NTSR1)
Contulakin Lt1 of Conus litteratus (Lettered cone)
Alpha-conotoxin OIVA or PrXA of 85 aas and 1 N-terminal TMS.
α-Conotoxin of Conus parius
Contulakin-G of 76 aas and 1 N-terminal TMS. Acts as an agonist of neurotensin receptors. It binds to human neurotensin type 1 receptor (NTSR1)
Contulakin-G of Conus geographus (Geography cone) (Nubecula geographus)