9.B.108 The Putative 7/8 TMS Porter (P7/8P) Family
Memberes of the P7/8P family usually exhibit 7 or 8 TMS and have lengths of 200 - 260 aas. Functional data are currently lacking. However, one family member, 9.B.108.1.4, gives a score of e-6 with 9.B.2.1.7, a putative CAAX2 protease with residues 25 - 207 (TMSs 1-6 or 7 (TMS 7 is very small) of the former protein aligning with residues 27 - 206 (TMSs 1-6) of the latter. Interestingly, only TMSs 7 - 11 in 9.B.2.1.7 align with other members of the CAAX2 family, and the N-terminal 6 TMSs of 9.B.2.1.7 align with TMSs 1-6 in three members of the MFS (2.A.1.2.5, 1.81 and 21.4). This suggests that 9.B.2.1.7 is a hybrid protein. Thus, the N-terminal 6 TMSs of 9.B.2.1.7 and P7/8P family members may be derived from the basic 6 TMS repeat unit of MFS porters.
Putative porter of 315 aas and 10 TMSs
PP of SAR86 cluster bacterium, SAR86A
Putative porter of 319 aas nad 8 TMSs
PP of Candidatus Actinomarina minuta
Putative porter of 214 aas and 7 TMSs
PP of Chlorobaculum parvum
Putative porter of 213 aas and 7 TMSs
PP of Oceanicola granulosus
Putative porter of 227 aas and 7 TMSs
PP of Herbaspirillum seropedicae
Putative porter of 269 aas and 8 TMSs
PP of Janibacter sp.