9.B.123 The Lysosomal 7-TMS (TM7SF1) Family

The TM7SF1 is a primarily lysosomal protein of 399aas in humans with 7 TMSs. It bears a dileucine-lysosomal targetting sequence and form putative N-glycosylation sites (Gao et al., 2012). Gao et al. (2012) suggest that it is a G-protein coupled receptor functioning in signal transduction across the lysosomal membrane. If so, it is very sequence divergent from the GPCR receptors in TC family 9.A.14. 


 

References:

Gao J., Xia L., Lu M., Zhang B., Chen Y., Xu R. and Wang L. (2012). TM7SF1 (GPR137B): a novel lysosome integral membrane protein. Mol Biol Rep. 39(9):8883-9.

Patel, K.B., E. Toh, X.B. Fernandez, A. Hanuszkiewicz, G.G. Hardy, Y.V. Brun, M.A. Bernards, and M.A. Valvano. (2012). Functional characterization of UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferases of Escherichia coli and Caulobacter crescentus. J. Bacteriol. 194: 2646-2657.

Examples:

TC#NameOrganismal TypeExample
9.B.123.1.1

TM7SF1 (Called the G-protein-coupled receptor, GPR137B). Co-localizes with LAMP2 (TC#9.A.16.1.2) (Gao et al., 2012). May belong to the WbaP (RfbP) Undecaprenyl phosphate galactose phosphotransferase family (Patel et al., 2012).

Animals

TM7SF1 of Homo sapiens (O60478)

 
9.B.123.1.2

G-protein-coupled receptor 137B of 386aas and 7 TMSs.

Animals

GPCR137B of Xenopus tropicalis (F6ULR8)

 
Examples:

TC#NameOrganismal TypeExample
9.B.123.2.1

Hypothetical protein of 298 aas and 6 TMSs

Slime molds

HP of Dictyostelium discoideum (Q54VM6)

 
9.B.123.2.2

Hypothetical protein of 286aas and 7 TMSs.

Plants

HP of Oryza sativa (B8B6I6)

 
Examples:

TC#NameOrganismal TypeExample
9.B.123.3.1

Hypothetical protein of 315aas and 7 TMSs.

Protozoa

HP of Entamoeba histolytica (C4M797)