9.B.124 The DUF805 or PF05656 (DUF805) Family

The DUF805 family consists of small proteins (~ 110 to 180aas) with 3 or 4 TMSs. In E. coli, YhaH and YhaI are homologous proteins that are encoded by adjacent genes.  They may encode a complete transport system as is often the case with SMR members of the DMT superfamily which can be either homodimeric or heterodimeric. In the latter case, the two homologoous genes usually map next to each other (Jack et al. 2001).


 

References:

Jack, D.L., N.M. Yang, and M.H. Saier, Jr. (2001). The drug/metabolite transporter superfamily. Eur J Biochem 268: 3620-3639.

Examples:

TC#NameOrganismal TypeExample
9.B.124.1.1

Inner membrane protein, YhaI (118aas; 3 TMSs)

Bacteria

YhaI of E. coli (P64592)

 
9.B.124.1.10

Uncharacterized protein of 231 aas and 3 TMSs

UP of Candidatus Saccharibacteria bacterium

 
9.B.124.1.2

YhaH (121aas; 3 TMSs)

Bacteria

YhaH of E. coli (P64591)

 
9.B.124.1.3

Putative aminopeptidase C (128aas; 3 TMSs)

Bacteria

Aminopeptidase C of Aggregatibacter actinomycetemcomitans (H0KI06)

 
9.B.124.1.4

Hypothetical protein (130aas; 3 TMSs)

Bacteria

HP of Streptococcus salivarius (G2GUD4)

 
9.B.124.1.5

YhaH homologue of 191 aas and 3 C-terminal TMSs.

YhaH of Tistrella mobilis

 
9.B.124.1.6

Uncharacterized protein of 142 aas and 3 TMSs.

UP of Xylanimonas cellulosilytica

 
9.B.124.1.7

Uncharacterized protein of 9 TMSs with TMSs 1 - 3 showing seqence similarity with other members of the family, but the last 6 TMSs of unknown origin.

UP of Phocaeicola abscessus

 
9.B.124.1.8

Uncharacterized protein of 191 aas and 3 TMSs

UP of Klebsiella oxytoca

 
9.B.124.1.9

Uncharacterized protein of 328 aas and 8 TMSs in a 4 + 4 TMS arrangement.

UP of Lactobacillus rhamnosus

 
Examples:

TC#NameOrganismal TypeExample
9.B.124.2.1

Uncharacterized protein of 135 aas and 4 TMSs.

UP of Asticcacaulis biprosthecum

 
9.B.124.2.2

Uncharacterized protein of 147 aas and 4 TMSs

Proteobacteria

UP of E. coli

 
9.B.124.2.3

Uncharacterized protein of 150 aas and 4 TMSs

UP of Asticcacaulis benevestitus