9.B.212 The Human Simplex Virus-1 gM protein (HSV-gM) Family Envelope glycoprotein M (gM), of 473 aas and 8 TMSs in a 4 + 4 arrangement, is important for virion assembly and egress. It plays a role in the incorporation of the gH-gL protein complex into the virion membrane. It also directs the glycoprotein N (gN) to the host trans-Golgi network. All of the transmembrane domain is essential for function (Striebinger et al. 2015; Striebinger et al. 2016).
References:
Striebinger, H., C. Funk, V. Raschbichler, and S.M. Bailer. (2016). Subcellular Trafficking and Functional Relationship of the HSV-1 Glycoproteins N and M. Viruses 8: 83.
Striebinger, H., J. Zhang, M. Ott, C. Funk, K. Radtke, J. Duron, Z. Ruzsics, J. Haas, R. Lippé, and S.M. Bailer. (2015). Subcellular trafficking and functional importance of herpes simplex virus type 1 glycoprotein M domains. J Gen Virol 96: 3313-3325.
Examples:
TC#	Name	Organismal Type	Example
9.B.212.1.1	*The HSV1 glycoportein M (gM) of 473 aas and 8 TMSs. Transports and inserts other proteins into membranes (Striebinger et al.* 2015; Striebinger et al. 2016).**		gM of Human Simplex Virus