9.B.218.  The DUF2324 (YhfC) Family of Putative Integral Membrane Metaloproteases (IMMP) Family 

The IMMP family (DUF2324) has been shown to be a member of a superfamily of integral membrane proteases (Pei et al. 2011).  On this basis, we propose the function of this family of proteins to be the same as other members of the proposed superfamily.


This family belongs to the CAAX Superfamily.
 

References:

Pei, J., D.A. Mitchell, J.E. Dixon, and N.V. Grishin. (2011). Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1. J. Mol. Biol. 410: 18-26.
Examples:

TC#NameOrganismal TypeExample
9.B.218.1.1

Putative integral membrane metalprotease of 250 aas and 7 TMSs

Membrane protein of Streptococcus pneumoniae

 
9.B.218.1.2

YhfC (DUF2324) family protein of 227 aas and 7 TMSs.

YhfC of Bacillus cereus

 
9.B.218.1.3

Uncharacterized transmembrane metaloproteinase of 235 aas and 7 TMSs.

UP of Nitrolancea hollandica

 
9.B.218.1.4

Putative protease of 263 aas and 6 TMSs.

PP of Actinomyces odontolyticus

 
Examples:

TC#NameOrganismal TypeExample
9.B.218.2.1

Intramembrane metalloprotease of the YhfC family 

YhfC protein of Ruminococcus flavefaciens

 
Examples:

TC#NameOrganismal TypeExample
9.B.218.3.1

YhfC family intramembrane metalloprotease of 262 aas and 7 TMSs.

YhfC protein of Methanocella conradii

 
9.B.218.3.2

YhfC family intramembrane metalloprotease of 400 aas and 7 TMSs.

UP of Levilinea saccharolytica